Clinical trial · Interventional
Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer
NCT07062172CI-TRIAL-00092117recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a single-armed screening research study which screens immediate family member of lung cancer patients with a driver mutation to see if lung cancer can be inherited and whether researchers can find lung cancer early. Immediate family members of lung cancer patients will be 40-80 years old and screened using a low dose CT scan.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Driver Mutation | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low Dose CT Scan | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Low Dose CT Scan of First Degree Relatives of Lung Cancer Patients
- description
- First degree relatives of patients with lung cancer with a known driver mutation will receive a low dose CT scan of the chest to screen for lung abnormality.
- interventionNames
- Diagnostic Test: Low Dose CT Scan
Primary outcomes (1)
- measure
- Number of lung cancers found
- timeFrame
- 2 years
- description
- Determine the number of lung cancers found in low dose CT scans of first degree relatives of lung cancer patients with known driver mutations.
Secondary outcomes (6)
- measure
- Number of follow-up CT scans
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Cohort A: Inclusion Criteria: * Current diagnosis of lung cancer with a driver mutation. * Known driver mutation (e.g. via NGS, PCR, IHC, FISH, RT-PCR etc.) * Able and willing to give informed consent. * Able and willing to complete the screening questionnaire. Cohort A: Exclusion Criteria: * There are no exclusion criteria for Cohort A. Cohort B: Inclusion Criteria: * Age 40 - 80. * Must have a first degree relative (mother, father, sibling, biological child) eligible for Cohort A. Note: Multiple first degree relatives of a Cohort A eligible participant may be approached for participation into the trial. * Smoked \< 20 pack years; a. Pack years = numbers of packs per day × number of years smoked; b. One pack year is the equivalent of smoking an average of 20 cigarettes (1 pack) per day for a year. * Be able to undergo a low dose chest CT scan. * If an upper respiratory infection (pneumonia, COVID19, flu, etc.) occurred in the last 3 months, this infection must have resolved by time of enrollment. * Able and willing to provide informed consent. * Able and willing to comply with the protocol requirements Cohort B: Exclusion Criteria: * Previous history of lung cancers. * Symptoms suggestive of presence of current lung cancer, including (but not limited to): unexplained weight loss of over 15 pounds within the last 12 months or unexplained hemoptysis. * Pregnant at time of enrollment. * History of any type of cancer within 5 years, with the exception of in situ carcinomas and non-melanoma skin cancers (if excised). * Current smoker. * Smoked ≥ 20 pack years. * Had a chest CT scan within 1 year of study entry.
References
Publications (0)
Data not yet available
No reference posted for this study.