Clinical trial · Interventional
Weight Management in Obese Cancer Patients During Curative Active Treatment
Weight Management in Obese Cancer Patients During Curative Active Treatment (CANOBESE Study): A Feasibility Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a feasibility study intervention to fifty cancer patients with obesity and with newly diagnosed stage II-IV solid tumors undergoing curative treatment recruited at the Catalan Institute of Oncology (ICO) in L'Hospitalet, Spain. The investigators hypothesize that weight management during cancer treatment could enhance health outcomes for this population. The feasibility of a multimodal weight loss management program will be assesses, including a personalized hypocaloric and high-protein diet combined with a supervised exercise home-program and behavioural support.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Curative Treatment | — | UNRESOLVED | — |
| Obesity | — | UNRESOLVED | — |
| Solid Neoplasm | Solid Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Stage II-IV | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Multimodal weight management program | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Cancer patients with obesity with active curative treatment
- description
- Fifty adult cancer patients with obesity (BMI ≥30 kg/m²) newly diagnosed with stage II-IV solid tumors undergoing curative-intent treatment. Participants will receive a multimodal weight management program combining dietary intervention, physicial activity and behavioral support.
- interventionNames
- Behavioral: Multimodal weight management program
Primary outcomes (6)
- measure
- Accrual
- timeFrame
- From baseline to end of cancer treatment (3 to 9 months)
- description
- Feasibility will be evaluated based on participant accrual, measured by the weekly enrollment rate and the total duration required to achieve the target sample size.
- measure
- Retention
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult (age 18+) with pathologically confirmed malignant solid tumors, stage II-IV, elected for oncological treatment (chemo, radio, or both) with curative intend. * Expected oncological treatment time ≥ 3 months. * BMI ≥ 30 kg/m² * Resident in the Barcelona area up to the completion of cancer treatment. * ECOG Perfomance Status (PS) 0-1 * Availability of internet access. Exclusion Criteria: * Patients with melanoma and brain tumours. * Surgery as the only treatment. * Tumour localizations with high risk of malnutrition (such as head and neck, upper gastrointestinal tract, or pancreatic cancer): * Pregnancy or breastfeeding * Another active malignancy * Current health or medical condition that affects weight status, e.g., untreated hyper- or hypothyroidism,etc * Pre-existing medical condition that precludes adherence to unsupervised exercise, e.g., severe orthopedic conditions, scheduled for a hip or knee replacement, bone metastases, paralysis, dementia, untreated stage 3 hypertension, or unstable angina, heart attack, congestive heart failure or conditions that dictated hospitalization or oxygen within 6-months. * Unable to read or understand Spanish or Catalan * Enrolled in a weight loss program * Active suicidal ideation, anorexia, bulimia, binge eating disorder, current substance abuse or dependence (besides nicotine dependence) * Use of pacemaker or another electrical implanted device * History of bariatric (or LapBand) surgery, or considering or currently on a wait-list for bariatric or LapBand surgery * Patients with any concurrent medical or psychological condition that, in the investigator's opinion, would jeopardize the safety of the patient or compliance with the protocol.
References
Publications (1)
- DERIVEDLlenas-Blade A, Puig Figueras M, Padilla Padilla C, Esteve A, Zamora-Ros R, Daura I Vidal M, Ochoa-Arnedo C, Pernas S, Santos Vivas C, Brenes J, Jimenez-Colomo L, Asiain L, Nadal E, Arribas L. Weight management in obese cancer patients during curative active treatment: protocol for the CANOBESE feasibility study. Pilot Feasibility Stud. 2026 Jun 24. doi: 10.1186/s40814-026-01868-w. Online ahead of print. PMID 42343485