Clinical trial · Interventional
Sequential Nutrition Intervention for Pancreatic Cancer Patients Undergoing CyberKnife Radiotherapy
Application Value of Sequential Nutrition Intervention Guided by Nutritional Risk Screening in CyberKnife Radiotherapy for Pancreatic Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to evaluate the clinical value of a structured nutritional support program for patients with pancreatic cancer undergoing CyberKnife radiotherapy. The study compares a sequential nutrition intervention, guided by nutritional risk screening, against routine nutritional advice. The goal is to determine if the structured intervention can better improve patients' nutritional status, immune function, and quality of life, while reducing the rate of postoperative complications.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Enteral Nutrition Emulsion | Drug | — | UNRESOLVED |
| Routine Nutritional Intervention | Behavioral | — | UNRESOLVED |
| Sequential Nutrition Intervention | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Experimental: Study Group
- description
- Participants received a structured, sequential nutrition intervention guided by nutritional risk screening (NRS2002). A multidisciplinary team provided the intervention, which included: * Pre-CyberKnife phase: Calculation of energy requirements using the Harris-Benedict formula, dietary guidance, and initiation of oral nutritional supplements (ONS). If oral intake was less than 60% of target, partial enteral (PEN) or parenteral nutrition (PPN) was administered for 7-10 days. * Post-CyberKnife phase: Phased re-introduction of feeding, starting with enteral nutrition via nasojejunal tube (Day 1-2) and transitioning to an oral diet (Day 3 onwards). * Post-discharge phase: Home energy targets were recalculated, with telephone/WeChat follow-up to ensure adherence. ONS prescribed if intake fell below 60% of targets.
- interventionNames
- Behavioral: Sequential Nutrition Intervention
- Drug: Enteral Nutrition Emulsion
- type
- ACTIVE_COMPARATOR
- label
- Active Comparator: Control Group
- description
- Participants received routine nutritional intervention, which consisted of dietary education focused on balanced, soft, and easily digestible meals rich in protein and other nutrients (e.g., high-protein soups).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of pancreatic cancer confirmed by pathological examination. * Capacity for oral intake. * Scheduled for CyberKnife treatment. * Presence of malnutrition, defined by Nutritional Risk Screening 2002 (NRS2002) score ≥3. * Expected survival \>6 months. * Karnofsky Performance Status (KPS) score ≥60. * Provided written informed consent. Exclusion Criteria: * Severe cardiovascular, hepatic, or renal dysfunction. * Concurrent malignancies of the digestive system. * Poor treatment compliance. * Severe ascites or edema. * Severe cognitive impairment hindering cooperation. * History of liver, kidney, or hematological diseases. * Bedridden status precluding nutritional assessment. * Long-term corticosteroid use. * Comorbidities affecting drug metabolism or excretion (e.g., AIDS, active hepatitis).
References
Publications (0)
Data not yet available