Clinical trial · Interventional
Tubeless VATS for Lung Cancer Surgery
A Prospective Randomized Controlled Study Evaluating Lung Injury, Long-term Clinical Outcomes, and Environmental Impact of Tubeless Versus Intubated Video-Assisted Thoracic Surgery for Lung Cancer Resection
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective cohort study evaluates lung injury, long-term clinical outcomes, and environmental impacts of tubeless video-assisted thoracic surgery (VATS) compared with conventional intubated VATS for lung cancer resection. The study aims to determine whether the tubeless approach reduces anesthetic exposure, minimizes lung injury, enhances patient recovery, and decreases carbon emissions, contributing toward sustainable surgical practices.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung | — | UNRESOLVED | — |
| Lung Cancer (NSCLC) | Malignant Lung Neoplasm | CURATED_EXACT | 0.85 |
| VATS | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Tubeless thoracic surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Tubeless group
- interventionNames
- Procedure: Tubeless thoracic surgery
- type
- OTHER
- label
- Intubation group
- interventionNames
- Procedure: Tubeless thoracic surgery
Primary outcomes (1)
- measure
- Lung Injury Assessment
- timeFrame
- Intraoperative period (from anesthesia induction to the end of surgery, approximately 1 to 3 hours)
- description
- Comparison of intraoperative mechanical power (MP) between tubeless and intubated VATS groups, quantified by a validated machine-learning model to evaluate ventilator-induced lung injury severity. Lower mechanical power indicates reduced lung stress and potential lung injury.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients aged ≥18 years scheduled for elective video-assisted thoracic surgery (VATS) for confirmed or suspected lung cancer. 2. Clinical stage suitable for surgical resection (lobectomy, segmentectomy, or wedge resection). 3. American Society of Anesthesiologists (ASA) physical status classification ≤III. 4. Ability to understand and willingness to provide written informed consent. 5. Agreement to adhere to scheduled postoperative clinical follow-up assessments, including pulmonary function tests and survival status evaluations. Exclusion Criteria: 1. Patients requiring bilateral pulmonary procedures or planned open thoracotomy. 2. History of severe cardiopulmonary disease or unstable medical conditions that contraindicate minimally invasive thoracic surgery. 3. Emergency surgery due to acute respiratory or cardiovascular instability. 4. Inability to cooperate with the planned anesthetic and surgical protocols or postoperative follow-up procedures. 5. Pregnancy or lactation at the time of enrollment. 6. Known allergy or contraindication to anesthetic agents or materials used in the study. 7. Enrollment in another interventional clinical study within the past 30 days.
References
Publications (0)
Data not yet available