Clinical trial · Interventional
Hyaluronic Acid for Prevention of Post-Intubation Sore Throat and Hoarseness
Effect of Hyaluronic Acid on Post-Intubation Sore Throat and Hoarseness in Breast Cancer Surgery: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to find out whether applying Endotra Gel, a hyaluronic acid-based gel, to the endotracheal tube can help reduce sore throat and hoarseness after surgery. These symptoms are common after general anesthesia when a endotracheal tube is placed into the trachea. They can cause discomfort and affect patient recovery. The main questions this study aims to answer are: * Does Endotra Gel reduce the chance of having a sore throat after surgery? * Does it help improve hoarseness or coughing after surgery? Participants in this study will: * Undergo general anesthesia for breast cancer surgery * Be randomly assigned to one of two groups: * One group will receive Endotra Gel applied to the endotracheal tube before intubation * The other group will have standard care with no gel * Be monitored for sore throat, hoarseness, and coughing right after surgery and on the day after surgery * Answer questions about their symptoms and satisfaction with their recovery The results will help researchers learn whether using Endotra Gel during intubation can improve patient comfort and reduce airway irritation after surgery.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Endotracheal Intubation | — | UNRESOLVED | — |
| General Anesthesia | — | UNRESOLVED | — |
| Postoperative Sore Throat, Cough, Hoarseness | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endotra Gel | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Endogra Gel Group
- description
- Participants will receive general anesthesia for breast cancer surgery. Endotra Gel, a hyaluronic acid-based gel, will be applied evenly on the surface of the endotracheal tube cuff prior to intubation.
- interventionNames
- Device: Endotra Gel
- type
- NO_INTERVENTION
- label
- No Gel Group
- description
- Participants will receive standard care for endotracheal intubation under general anesthesia without application of any gel or lubricant to the endotracheal tube.
Primary outcomes (1)
- measure
- Incidence and Severity of Postoperative Sore Throat
- timeFrame
- Up to 1 hour after extubation at PACU
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged 19 to 80 years * Scheduled to undergo breast cancer surgery under general anesthesia with endotracheal intubation * American Society of Anesthesiologists (ASA) physical status I to III Exclusion Criteria: * Mallampati classification of III or higher * Recent upper respiratory infection or symptoms of upper airway infection * Pre-existing laryngeal disease or chronic respiratory conditions (e.g., asthma, chronic bronchitis) * Current use of systemic steroids * Refusal to provide informed consent * Determined to be unsuitable for study participation by the investigator
References
Publications (0)
Data not yet available