Clinical trial · Interventional
Clinical Alternatives for Reducing Harm Using E-cigarettes
A Novel Harm Reduction Approach for Oncology Outpatients Who Smoke and Refuse Traditional Tobacco Treatment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
For patients in cancer care, quitting smoking is critical, but a significant portion of patients in cancer care refuse all components of tobacco treatment, even when offered free of charge. The proposed clinical trial will assess one harm reduction intervention, switching completely from cigarettes to e-cigarettes, among oncology outpatients who smoke and refuse traditional tobacco treatment. This study is a type 1 hybrid effectiveness-implementation trial among oncology outpatients at an NCI-designated cancer center who smoke and refuse all components of tobacco treatment (N=208).
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| E-Cig Use | — | UNRESOLVED | — |
| Oncology | — | UNRESOLVED | — |
| Smoking | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Harm Reduction (E-cigarette switching) | Behavioral | — | UNRESOLVED |
| Standard of Care | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Harm Reduction (E-cigarette switching)
- description
- Participants will be assigned to receive an e-cigarette and try to switch completely from smoking to using the e-cigarette
- interventionNames
- Behavioral: Harm Reduction (E-cigarette switching)
- type
- ACTIVE_COMPARATOR
- label
- Standard of Care
- description
- Participants will be assigned to receive tobacco treatment referrals and the opportunity to re-enroll in the Tobacco Treatment Program
- interventionNames
- Behavioral: Standard of Care
Primary outcomes (1)
- measure
- Complete switching
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: * age 21+, * identified as smoking in their medical record and self-report of current smoking within the past 30 days * refused traditional treatment options through the opt-out HCC Tobacco Treatment Program * English speaking; Exclusion Criteria: * currently taking part in any TTP or using cessation medication (i.e., taking NRT or other cessation medications, enrolled in the Quitline, or in another study), * use of e-cigarettes in the past 30 days, * currently imprisoned, * pregnant women.
References
Publications (0)
Data not yet available