Clinical trial · Observational
Transmission of Oncogenic HPV Infection Among Families
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of the Transmission of Oncogenic HPV Infection Among Families (TREVINO) study is to improve understanding of how high-risk human papillomavirus (HPV) infections are transmitted within families. The research focuses on transmission between sexual partners and between parents and children. It also examines how the various microbes may influence the persistence of HPV infections and the development of HPV-related cancers. The study will include up to 300 couples recruited from gynecology and ear, nose, and throat (ENT) clinics in Finland, as well as their children. Participants include individuals with persistent HPV infection, cervical precancer or cancer, or HPV-related head and neck cancer, along with their partners and potentially their offspring. Participants will provide self-collected samples from the oral and genital areas at multiple time points over up to five years. Questionnaires addressing medical, behavioural, and environmental factors will be completed. The study is conducted at Tampere University Hospital and Kuopio University Hospital in Finland. Results will inform HPV screening and prevention programs, improve understanding of family-level transmission, and identify potential microbial and genetic markers linked to cancer risk.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Carcinoma | Cervical Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Human Papilloma Virus (HPV) | — | UNRESOLVED | — |
| Human Papillomavirus Infection | — | UNRESOLVED | — |
| Oropharyngeal Carcinoma | Oropharyngeal Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Transmission | — | UNRESOLVED | — |
| Transmission Vertical | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Patients with HPV associated disease
- description
- 1\) colposcopy clinic detected persisting HR-HPV infection, 2) diagnosed cervical cancer; or 3) diagnosed Oral squamous cell carcinoma (OSCC).
- label
- Offspring of patients with HPV associated disease
- description
- Children over 12 years old
- label
- Sexual partner (spouse) of patients with HPV associated disease
- description
- Women or men
Primary outcomes (1)
- measure
- HPV genotype among patients with HPV associated disease and their sexual couples
- timeFrame
- From enrollment to 24 month follow-up samples
- description
- All oral and genital samples are genotypes using extended HPV genotyping assays that detect at least 25 different HPV genotypes separately.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with colposcopy clinic detected persisting HR-HPV infection * Patient with diagnosed cervical cancer * Patient with diagnosed OSCC * Patients' sexual partners of women or men that are referred to the colposcopy/gynecological oncology/ENT * offspring (over 12 years old) of the referred couples Exclusion Criteria: * Candidate who don't speak Finnish
References
Publications (0)
Data not yet available