Clinical trial · Observational
Biological Age Predicts 90-Day Mortality in Advanced Cancer
Biological Age as a Prognostic Marker in Hospitalized Patients With Advanced Cancer: A Retrospective Analysis Based on PhenoAge Model
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This retrospective study evaluates whether biological age, calculated using the PhenoAge model, predicts short-term outcomes in patients with advanced cancer who were hospitalized. The main goal is to investigate associations between biological age and short-term mortality, functional status (ECOG), comorbidity burden (mCCI), and length of hospital stay. All data were collected from medical records without any patient intervention.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Solid Tumors Cancer | — | UNRESOLVED | — |
| Hospitalizations | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PhenoAge-Based Biological Age Assessment | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Hospitalized Advanced Cancer Patients
- description
- Patients hospitalized with advanced solid tumors (Stage III or IV) in the oncology clinic were retrospectively analyzed. Biological age was calculated using the PhenoAge model. Clinical outcomes such as mortality, ECOG score, mCCI, and length of stay were assessed.
- interventionNames
- Other: PhenoAge-Based Biological Age Assessment
Primary outcomes (1)
- measure
- 90-Day All-Cause Mortality
- timeFrame
- Up to 90 days post-admission
- description
- All-cause mortality within 90 days following the date of hospital admission (index hospitalization).
Secondary outcomes (1)
- measure
- Modified Charlson Comorbidity Index (mCCI)
- timeFrame
- Baseline (Day of hospital admission)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Hospitalized in the Medical Oncology Department between November 5, 2022, and December 31, 2024 Histologically confirmed advanced-stage (stage III-IV) solid tumors Age ≥18 years Hospital stay of at least 48 hours Actively receiving chemotherapy or received it within the last 6 months Availability of all 9 required laboratory tests (albumin, creatinine, glucose, CRP, lymphocyte %, MCV, RDW, ALP, WBC) for PhenoAge calculation during the first admission Patients with multiple hospitalizations who meet the inclusion criteria will be included Exclusion Criteria: * Elective hospitalizations (e.g., planned chemotherapy, biopsy) Patients who died during the first admission Missing required laboratory parameters ICU patients and unconscious patients
References
Publications (0)
Data not yet available