Clinical trial · Interventional
Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer Screening
NCT07033091CI-TRIAL-00103307recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study defines the prevalence of oral infection with high-risk human papillomaviruses (hrHPV) in individuals over 40 years of age in the Czech Republic. It also establishes an effective methodology for oropharyngeal carcinoma screening and optimization of screening and testing procedures.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oropharynx Cancer | Malignant Oropharyngeal Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood sampling | Diagnostic Test | — | UNRESOLVED |
| Questionnaire | Other | — | UNRESOLVED |
| Self-sampling by gargling kit at dental clinic | Diagnostic Test | — | UNRESOLVED |
| Self-sampling by gargling kit at home | Diagnostic Test | — | UNRESOLVED |
| Self-sampling of the urogenital area | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm A
- description
- Participants over 40 years attending cooperating dental clinics, who agree to the study, complete questionnaire and provide self-sampled gargling sample. These will be tested by CE-IVD-marked HPV diagnostic test. This arm will include approx. 10000 participants.
- interventionNames
- Diagnostic Test: Self-sampling by gargling kit at dental clinic
- Other: Questionnaire
- Diagnostic Test: Blood sampling
- Diagnostic Test: Self-sampling of the urogenital area
- type
- EXPERIMENTAL
- label
- Arm B
- description
- Participants over 40 years selected from available databases receive by mail the study information, questionnaire and self-sampling gargling kit. The kits will be sent back to laboratory and will be tested by CE-IVD-marked HPV diagnostic test. This arm will include approx. 10000 participants.
- interventionNames
- Other: Questionnaire
- Diagnostic Test: Self-sampling by gargling kit at home
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Participants aged 40 years or older at the time of enrollment. * Individuals who are capable of rinsing the oral cavity by gargling independently. * Signed informed consent for study participation, molecular-genetic testing, and personal data processing. Exclusion Criteria: \- Previously diagnosed head and neck cancer.
References
Publications (0)
Data not yet available
No reference posted for this study.