A Study to Evaluate the Safety and Tolerability of EP0089

Inclusion Criteria:

Applicable to all patients:

1. Must be ≥18 years of age (≥19 in South Korea) with documented recurrent, metastatic or unresectable solid tumours for whom no standard therapy exists or standard therapy has failed
2. ECOG performance status of 0 or 1 and life expectancy \>3 months at screening
3. Ability to understand and provide written informed consent
4. Must be willing to comply with necessary contraceptive methods as required
5. Willing and able to comply with the scheduled study treatment plan, laboratory tests, and other study procedures.
6. Adequate hepatic, haematological and renal function as assessed by protocol-defined criteria.
7. Additional cohort/disease specific criteria apply
8. Measurable disease per RECIST v1.1

Exclusion Criteria:

1. Known active CNS metastases and/or leptomeningeal disease and/or carcinomatous meningitis.
2. Recent major surgery
3. Recent live or live-attenuated vaccine ≤ 30 days prior to the first dose
4. Current active, or history of, autoimmune disease that requires or required systemic treatment (ie, with disease modifying agents, corticosteroids, or immunosuppressive drugs) within 2 years prior to starting study treatment.
5. Prior severe hypersensitivity reaction to mAbs
6. Previous \> Grade 2 peripheral neuropathy.
7. Significant neurological condition eg stroke, transient ischaemic attack (in the last 12 months), epilepsy, head trauma, brain surgery or prior history of any significant psychiatric disorder

9\. Current active, or history of, autoimmune disease that requires or required continuous treatment within 2 years prior to starting study treatment

10\. Receiving chronic systemic steroid therapy (\> 10 mg /day of prednisone or equivalent) or any other form of immunosuppressive therapy ≤ 7 days prior the first dose of study drug. Topical or inhaled steroids are permitted.

11\. Any prior immune-mediated or immune-related adverse events related to treatment with immune-modulatory agents that caused permanent discontinuation of the agent, that were ≥ Grade 3 in severity or in the opinion of the Investigator would otherwise jeopardise patient safety in this study.

12\. One or more clinically significant (ie, active) cardiovascular diseases, myocardial infarction, or unstable angina (≤ 6 months prior to first administration of study drug)