Clinical trial · Observational
Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis
NCT07022028CI-TRIAL-00091123GUIMAUVEcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols. To date, no study has compared weaning modalities from mechanical ventilation in patients with these two diseases. Our objective was to assess and compare for ventilator weaning modalities between patients mechanically ventilated for Guillain-Barré syndrome or for myasthenia gravis in a large-scale multicenter study.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Guillain-Barre Syndrome | — | UNRESOLVED | — |
| Myasthenia Gravis | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Patients mechanically ventilated for Guillain-Barré syndrome or for myasthenia gravis (two groups)
Primary outcomes (1)
- measure
- The proportion of patients with prolonged weaning
- timeFrame
- 7 days after the initial separation attempt from the ventilator
- description
- Prolonged weaning defined as still being under mechanical ventilation at least 7 days after the initial separation attempt from the ventilator
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: All patients mechanically ventilated for at least 48 hours for Guillain-Barré syndrome or myasthenia gravis - Exclusion Criteria: Patients mechanically ventilated less than 48h or intubated for another reason than the neuromuscular disease. \-
References
Publications (2)
- DERIVEDThille AW, Bayon C, Gauvrit M, Saccheri C, Labruyere M, Beduneau G, Wattecamps G, Henry M, Bendiab E, Swinyard B, Gacouin A, Celier A, Foucou B, Champion S, Haudebourg AF, Dangers L, Plateker O, Daubin C, Fromont L, Guesdon C, Vivier E, Volkov L, Potier C, Bourenne J, Chiquet C, Pointurier V, Chauvelot L, Bailly P, Schnell D, Sedillot N, Reizine F, Argaud L, Reynaud F, Pelle J, Lesieur O, Auvet A, Lacave G, Kernevez M, Contou D, Grillet G, Delahaye A, Badie J, Devaquet J, Chauvin H, Beurton A, Turbil E, Rigaud JP, Ragot S, Chamblet L, Le Pape S, Coudroy R. Effects of direct tracheostomy on ventilator weaning in patients intubated for Guillain-Barre syndrome. Ann Intensive Care. 2026 Jul 28;16:100124. doi: 10.1016/j.aicoj.2026.100124. eCollection 2026. PMID 42592412
- DERIVEDThille AW, Bayon C, Gauvrit M, Saccheri C, Labruyere M, Beduneau G, Wattecamps G, Henry M, Bendiab E, Swinyard B, Gacouin A, Celier A, Foucou B, Champion S, Haudebourg AF, Dangers L, Plateker O, Daubin C, Fromont L, Guesdon C, Vivier E, Volkov L, Potier C, Bourenne J, Chiquet C, Pointurier V, Chauvelot L, Bailly P, Schnell D, Sedillot N, Reizine F, Argaud L, Reynaud F, Pelle J, Lesieur O, Auvet A, Lacave G, Kernevez M, Contou D, Grillet G, Delahaye A, Badie J, Devaquet J, Chauvin H, Beurton A, Turbil E, Rigaud JP, Ragot S, Chamblet L, Coudroy R, Le Pape S. Characteristics of ventilator weaning in patients intubated for Guillain-Barre syndrome or myasthenia gravis: a nationwide multicenter study. Intensive Care Med. 2025 Nov;51(11):2054-2064. doi: 10.1007/s00134-025-08159-7. Epub 2025 Oct 20. PMID 41114833