Clinical trial · Observational
Sex Differences in Gastrointestinal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to investigate whether there are differences in surgical outcomes between male and female patients with gastrointestinal cancers (esophagus, colon, rectum, stomach, or pancreas). Previous research suggests that women may have worse outcomes after high-risk surgeries, such as heart or vascular procedures, but it is unclear if this applies to gastrointestinal cancer surgery. The study will analyze population based data from Germany to compare how often male and female patients died or died after the occurence of a surgical complication (failure to rescue) after surgery. The goal is to determine if biological sex influences surgical risks and recovery, which could help improve personalized care for cancer patients.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastrointestinal Cancers | Malignant Digestive System Neoplasm | ALIAS | 0.90 |
| Sex | — | UNRESOLVED | — |
| Sex Differences | — | UNRESOLVED | — |
| Surgical Resection | — | UNRESOLVED | — |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Colon resection for carcinoma | Procedure | — | UNRESOLVED |
| Complex esophageal surgery for carcinoma | Procedure | — | UNRESOLVED |
| Gastric resection for carcinoma | Procedure | — | UNRESOLVED |
| Pancreatic resection for carcinoma | Procedure | — | UNRESOLVED |
| Rectum resection for carcinoma | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Male patients
- interventionNames
- Procedure: Complex esophageal surgery for carcinoma
- Procedure: Rectum resection for carcinoma
- Procedure: Colon resection for carcinoma
- Procedure: Pancreatic resection for carcinoma
- Procedure: Gastric resection for carcinoma
- label
- Female patients
- interventionNames
- Procedure: Complex esophageal surgery for carcinoma
- Procedure: Rectum resection for carcinoma
- Procedure: Colon resection for carcinoma
- Procedure: Pancreatic resection for carcinoma
- Procedure: Gastric resection for carcinoma
Primary outcomes (2)
- measure
- Mortality rate
- timeFrame
- Up to 90 days postoperatively
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * at least 18 years old at the time of the operation * Rectum resection for carcinoma (ICD-10: C19, C20, C218, D01.1, D01.2) and appropriate resection procedure (5-484, 5-485) * Colon resection for carcinoma (ICD-10: C18, D01.0) and appropriate resection procedure (5-455, 5-456, 5-458) * Complex esophageal surgery for carcinoma (ICD-10: C15, C16.0) and appropriate resection procedure (5-423, 5-424, 5-425, 5-426, 5-427.0, 5-427.1, 5-438.0, 5-438.1, 5-438.x) * Pancreatic resection for carcinoma (ICD-10: C25, C24.1) and appropriate resection procedure (5-524, 5-525.0, 5-525.1, 5-525.2, 5-525.x, 5-525.y, 5-528) * Gastric resection for carcinoma (ICD-10: C16) and appropriate resection procedure (5-436, 5-437, 5-438) Exclusion Criteria: * missing data for age and/or sex * implausible combination of diagnosis and resection procedure (eg. a patient with a gastrectomy but without appropriate ICD-10 diagnosis)
References
Publications (0)
Data not yet available