Clinical trial · Interventional
Cognitive Training and Exercise for Women With Breast Cancer and Cognitive Impairment
Combined Intervention of Cognitive Training and Supervised Physical Exercise for Women With Breast Cancer and Chemotherapy-Related Cognitive Impairment: Study Protocol for a Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chemotherapy-related cognitive impairment is a prevalent and distressing condition among breast cancer survivors, adversely affecting memory, attention, and overall cognitive function, thereby diminishing quality of life. Emerging evidence suggests that multimodal interventions combining cognitive training and adapted physical exercise may mitigate these cognitive deficits and associated symptoms. This study aims to evaluate the efficacy of a 12-week structured intervention integrating cognitive training and supervised physical exercise in improving cognitive function, fatigue, sleep quality, psychological distress, and overall well-being in women with breast cancer. Furthermore, it seeks to determine the optimal timing for such interventions to maximize their effectiveness. A randomized controlled trial involving 220 participants will assess subjective and objective cognitive outcomes, brain activity, and physical performance. The findings from this research may contribute to the development of evidence-based rehabilitation strategies, enhancing cognitive health and quality of life in breast cancer patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cognitive training | Other | — | UNRESOLVED |
| Psychoeducational therapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Cognitive training + exercise group during chemotherapy
- description
- Al list two cycles of chemotherapy.
- interventionNames
- Other: Cognitive training
- type
- EXPERIMENTAL
- label
- Cognitive training + exercise group after chemotherapy
- description
- Al list six months after the completion of chemotherapy.
- interventionNames
- Other: Cognitive training
- type
- ACTIVE_COMPARATOR
- label
- Psychoeducational therapy during chemotherapy
- description
- Al list two cycles of chemotherapy.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Women aged 18 years or older who were diagnosed with stage 0 to IV breast cancer. * Women undergoing chemotherapy (at least two cycles) or having completed it at least six months earlier. * Cognitive impairment must be reported, with scores below 54 on the FACT-Cog scale Exclusion Criteria: * Women with significant neurological conditions. * Women with psychiatric conditions. * Women with contraindications for physical exercise.
References
Publications (0)
Data not yet available