Clinical trial · Interventional
Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment
Using Fractional Lasers and Tirbanibulin Ointment to Treat Keratinocyte Carcinomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators seek to evaluate the effectiveness of fractional laser therapy and tirbanibulin ointment to treat squamous and basal cell carcinomas. This will be executed by using both thulium and erbium lasers on previously biopsy-confirmed SCCs and BCCs and applying bulk heating methods. Then, depending on the level of invasiveness, subjects may be instructed to apply the ointment over the course of five nights immediately following the treatment. The intention of this study is to minimize the need for invasive surgical procedures so as to optimize the cosmetic appearance, and provide a treatment option that is beneficial for a wide range of individuals.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Basal Cell Carcinomas | Basal Cell Carcinoma | ONTOLOGY_EXACT | 0.90 |
| Keratinocyte Carcinoma | Skin Neoplasm | PROBABILISTIC | 0.70 |
| Skin Cancer | Malignant Skin Neoplasm | ALIAS | 0.90 |
| Squamous Cell Carcinoma | Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| non-ablative fractional laser | Device | — | UNRESOLVED |
| Tirbanibulin ointment 1% | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Fractional Laser Only
- description
- Treatment of superficial or in situ carcinomas will be with fractional laser only.
- interventionNames
- Device: non-ablative fractional laser
- type
- ACTIVE_COMPARATOR
- label
- Fractional Laser and Tirbanibulin Ointment
- description
- Treatment of nodular or invasive carcinomas will be with fractional laser followed by a course of Klisyri ointment.
- interventionNames
- Drug: Tirbanibulin ointment 1%
- Device: non-ablative fractional laser
Primary outcomes (1)
- measure
- Clearance of skin cancer by evidence of no clinical and/or histological recurrence after 5 years.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: biopsy confirmed squamous and/or basal cell carcinoma not previously treated by another method. Exclusion Criteria: * Cannot be pregnant at the time of treatment
References
Publications (1)
- RESULTRobinson BP, Nanni GM. Utilizing fractional lasers and tirbanibulin ointment to treat squamous and basal cell carcinomas. Arch Dermatol Res. 2024 Oct 14;316(10):683. doi: 10.1007/s00403-024-03423-0. PMID 39400600