Clinical trial · Observational
Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery
The Effects of Sarcopenia on Neuromuscular Block in Gastrointestinal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective observational study aims to evaluate the effects of sarcopenia on intraoperative neuromuscular block (NMB) in patients undergoing gastrointestinal cancer surgery. Adult patients scheduled for elective gastrointestinal cancer surgery will be grouped as sarcopenic or non-sarcopenic based on preoperative abdominal CT scans. Neuromuscular block parameters, including onset time, depth, duration, and recovery, will be objectively measured using TOF (Train-of-Four) monitoring. The study seeks to determine whether sarcopenia influences sensitivity to muscle relaxants and to contribute to individualized anesthesia management and patient safety.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastrointestinal Cancer | Malignant Digestive System Neoplasm | ALIAS | 0.90 |
| Neuromuscular Blockade | — | UNRESOLVED | — |
| Sarcopenia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Standard Anesthesia Management | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Sarcopenic
- description
- Patients with gastrointestinal cancer scheduled for elective surgery who are identified as sarcopenic based on preoperative abdominal CT scans at the L3 vertebral level, according to established cut-off values.
- interventionNames
- Procedure: Standard Anesthesia Management
- label
- Non-Sarcopenic
- description
- Patients with gastrointestinal cancer scheduled for elective surgery who are identified as non-sarcopenic based on preoperative abdominal CT scans at the L3 vertebral level, according to established cut-off values.
- interventionNames
- Procedure: Standard Anesthesia Management
Primary outcomes (4)
- measure
- Onset Time of Neuromuscular Block
- timeFrame
- Intraoperative (from induction until adequate block is achieved)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged between 18 and 75 years * Patients diagnosed with gastrointestinal system (GIS) cancer and scheduled for elective surgery * Patients who have undergone preoperative abdominal computed tomography (CT) imaging * Patients classified as American Society of Anesthesiologists (ASA) physical status I-III Exclusion Criteria: * Patients with a history of neuromuscular diseases * Patients receiving chronic steroid or immunosuppressive therapy * Patients with electrolyte imbalance * Patients using medications that affect neuromuscular transmission * Patients with severe organ failure in the preoperative period (e.g., liver or renal failure) * Patients who refuse to participate in the study * Patients requiring emergency surgery * Patients using muscle relaxants in the preoperative period
References
Publications (2)
- BACKGROUNDAlmeida PS, Barao K, Forones NM. SARCOPENIA AND GASTROINTESTINAL CANCER: NUTRITIONAL APPROACH FOCUSING ON CURCUMIN SUPPLEMENTATION. Arq Gastroenterol. 2025 Apr 4;62:e24068. doi: 10.1590/S0004-2803.24612024-068. eCollection 2025. PMID 40197883
- BACKGROUNDClark BC. Neuromuscular Changes with Aging and Sarcopenia. J Frailty Aging. 2019;8(1):7-9. doi: 10.14283/jfa.2018.35. PMID 30734824