Clinical trial · Interventional
The Impact of MTM Model on the Efficacy and Safety of Anticoagulant Therapy in Postoperative Colorectal Cancer Patients
NCT06998745CI-TRIAL-00090448recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Anticoagulants are classified as high-risk medications, with their main adverse drug events (ADEs) being recurrent venous thromboembolism (VTE) and bleeding events.Postoperative colorectal cancer (CRC) patients exhibit a high probability of recurrent VTE and bleeding during anticoagulation therapy.The Medication Therapy Management (MTM) model will contribute to reducing ADEs associated with anticoagulants in CRC patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thrombosis, Venous | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Medication Therapy Management (MTM) model | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intervention group patients will receive anticoagulation management via MTM model
- interventionNames
- Behavioral: Medication Therapy Management (MTM) model
- type
- NO_INTERVENTION
- label
- Control group patients will be managed using a standard care.
Primary outcomes (1)
- measure
- Clinically Important Medication Errors (CIME) related to anticoagulant therapy
- timeFrame
- From the time of the patient's admission to 6 months after discharge.
- description
- The primary outcome is CIME related to anticoagulation therapy, which constitute a composite endpoint comprising preventable or ameliorable adverse drug events (ADEs) and potential ADEs arising from medication discrepancies or non-adherence. The primary anticoagulant-related ADEs that this trial plans to observe encompass two categories: (i) ADEs associated with the therapeutic effects of anticoagulant, including all-cause mortality, suspected recurrence of deep vein thrombosis (DVT) and pulmonary embolism (PE), confirmed symptomatic or incidental DVT, and confirmed symptomatic or incidental PE; (ii) ADEs related to the major adverse drug reactions, such as major bleeding, clinical related non-major bleeding, and minor bleeding.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with histologically confirmed CRC and symptomatic or incidental VTE who received anticoagulant treatment. 2. CRC patients with VTE treated with an anticoagulant for at least 3 moths. Exclusion Criteria: 1.Participation in this study required active anticoagulant treatment. Apart from this, there were no specific exclusion criteria.
References
Publications (1)
- DERIVEDMao J, Liang Z, Gao M, Huang X, Xie J, Dai C, Zhao J, Ding Y, Ye G, Wang Y, Qin L, Li X. Protocol for the impact of medication therapy management on efficacy and safety of postoperative anticoagulation therapy in patients with colorectal cancer: an open-label, prospective and randomized clinical trial. Chin Clin Oncol. 2026 Feb;15(1):6. doi: 10.21037/cco-25-111. PMID 41797454