Clinical trial · Interventional
Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73
NCT06995976CI-TRIAL-00090342recruitingEarly Phase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. In this study, we observed the safety, biodistribution and radiation dosimetry of 68Ga-dPNE in human volunteers. Furthermover, we conducted a comparative analysis of 68Ga-dPNE and 18F-FDG imaging to assess both the radiation dosimetry and diagnostic efficacy of 68Ga-dPNE.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Tumour | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 18F-FDG | Drug | — | UNRESOLVED |
| 68Ga-dPNE | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 68Ga-dPNE PET/CT
- description
- Intravenous injection of 68Ga-dPNE. 68Ga-dPNE PET/CT will be used to detect tumors.
- interventionNames
- Drug: 68Ga-dPNE
- type
- EXPERIMENTAL
- label
- 18F-FDG PET/CT
- description
- Intravenous injection of 18F-FDG. 18F-FDG PET/CT will be used to detect tumors.
- interventionNames
- Drug: 18F-FDG
Primary outcomes (1)
- measure
- SUV of tumors
- timeFrame
- Through study completion, an average of 3 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: Signed informed consent and be able to follow up. Exclusion Criteria: Pregnant or lactational women; who suffered from severe hepatic and renal insufficiency.
References
Publications (0)
Data not yet available
No reference posted for this study.