Clinical trial · Observational
US Radiomics in Advanced Cervical Cancer
Role of Radiomics Applied to Ultrasound in Patients With Locally Advanced Cervical Cancer: a Retrospective Multicenter Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a retrospective, multicenter observational study aimed at evaluating the role of ultrasound-based radiomics in patients with locally advanced cervical cancer (LACC). The study will analyze pre-treatment ultrasound images to identify radiomic features that may predict treatment response and disease recurrence. A total of 220 patients treated with exclusive chemoradiotherapy or neoadjuvant chemoradiotherapy followed by radical surgery between 2011 and 2024 will be included. Using clinical and imaging data, machine learning models will be developed to distinguish between responders and non-responders, and to identify patients at higher risk of relapse. The goal is to improve personalized care in LACC by integrating radiomic analysis into treatment planning and follow-up strategies.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chemoradiotherapy | — | UNRESOLVED | — |
| Locally Advanced Cervical Cancer | Malignant Cervical Neoplasm | CURATED_BROADER | 0.78 |
| Machine Learning | — | UNRESOLVED | — |
| Radiomics | — | UNRESOLVED | — |
| Ultrasound Imaging | — | UNRESOLVED | — |
| Uterine Cervical Neoplasms | Cervical Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radiomic Analysis of Ultrasound Images | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Responder Group
- description
- Patients with locally advanced cervical cancer who responded to primary treatment (either exclusive chemoradiotherapy or neoadjuvant chemoradiotherapy followed by radical surgery), as determined by clinical and/or histological assessment.
- interventionNames
- Other: Radiomic Analysis of Ultrasound Images
- label
- Non-Responder Group
- description
- Patients with locally advanced cervical cancer who did not respond to primary treatment (either exclusive chemoradiotherapy or neoadjuvant chemoradiotherapy followed by radical surgery), based on residual disease findings or lack of clinical response.
- interventionNames
- Other: Radiomic Analysis of Ultrasound Images
Primary outcomes (1)
- measure
- Performance of ultrasound-based radiomic models in predicting treatment response in patients with locally advanced cervical cancer.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Female patients aged ≥18 years Histologically confirmed diagnosis of locally advanced cervical cancer (FIGO 2018 stage IB3-IVA, excluding IIA1) Histologic subtypes: squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma Underwent transvaginal or transrectal ultrasound prior to treatment At least one pre-treatment DICOM ultrasound image of the primary tumor available Treated with either exclusive chemoradiotherapy or neoadjuvant chemoradiotherapy followed by radical surgery Completed at least 12 months of follow-up after primary treatment Signed informed consent (or equivalent declaration) Exclusion Criteria: Age \<18 years Only printed ultrasound images available Ultrasound images with poor tumor visualization or with text/markers obscuring the tumor
References
Publications (0)
Data not yet available