Clinical trial · Interventional
Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance
FIT Versus Colonoscopy for Post-polypectomy Surveillance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Colonoscopy | Diagnostic Test | — | UNRESOLVED |
| Fecal occult blood testing | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Colonoscopy
- description
- Colonoscopy surveillance after polyp removal
- interventionNames
- Diagnostic Test: Colonoscopy
- type
- EXPERIMENTAL
- label
- Fecal blood testing
- description
- Fecal testing as surveillance after polypectomy
- interventionNames
- Diagnostic Test: Fecal occult blood testing
Primary outcomes (1)
- measure
- Colorectal cancer incidence
- timeFrame
- 12 years from randomization
Secondary outcomes (9)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * High-quality baseline colonoscopy with adequat cleansing and cecal intubation * Remocval of at least one advanced adenoma * Clean colon (all polyps removed) * Signed informed consent Exclusion Criteria: * Colorectal cancer * History of surgical colon resection for any reason * Genetic cancer syndrome (adenomatous or serrated polyposis syndrome; Lynch or Lynch-like syndrome) * ≥ 10 adenomas at baseline colonoscopy (cumulative) * History of advanced serrated lesion, defined as SSL≥ 10mm or with dysplasia * Inflammatory bowel disease * On-going palliative care for any reason
References
Publications (0)
Data not yet available