Clinical trial · Observational
Evaluation of the Neurologic Assessment in Pediatric Neuro-Oncology (pNANO)
NCT06981156CI-TRIAL-00118838recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to investigate a neurologic exam scale to provide an objective and more standard way to assess tumor response in pediatric patients with brain and spinal cord tumors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pediatric Brain Tumor | Childhood Brain Neoplasm | ALIAS | 0.90 |
| Pediatric Spine Tumor | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| pNANO Assessment | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Pediatric Brain and Spine Tumor Patients
- interventionNames
- Diagnostic Test: pNANO Assessment
Primary outcomes (1)
- measure
- Inter-observer Variability in pNANO Scores: Difference in Mean Cumulative Scores
- timeFrame
- Visit 1 (baseline), Visit 2 (up to 6 months)
- description
- The Pediatric Neurologic Assessment in Neuro-Oncology (pNANO) is scored in multiple domains: - strength, level of consciousness, and gait domains (each individually scored 0-3) * facial strength, cerebellar function, visual fields, extraocular movements, dysphagia, and dysarthria domains (each individually scored 0-2) * visual acuity domain scored from 0-1 If summed, cumulative scores range from 0 (normal) to 22 (inability to function in each relevant domain) Investigators will explore variability across all domains.
Secondary outcomes (2)
- measure
- Feasibility: Clinical Exams that may correlate with pNANO scores
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 1 Year
- Maximum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: * greater than or equal to 1 year old * must be seen in the pediatric clinic * Radiographic or histologic confirmation of a brain or spine tumor at the time of initial diagnosis * Patient or parent/guardian must be able to understand the consent and be willing to sign a written informed consent document according to institutional guidelines. Exclusion Criteria: * none specified
References
Publications (0)
Data not yet available
No reference posted for this study.