HIghly MetAstatic Life Prolonging Therapy-Resistant Prostate Cancer: Role of Stereotactic Radiotherapy for Bone and Lymph Node Metastases (HIMARS)

Inclusion Criteria:

* Metastatic prostate cancer with clinical progression after the use of androgen-receptor pathway inhibitor, chemotherapy or any other life-prolonging therapy. Patient could have been treated previously by RadioLigand Therapy (RLT).
* Performance Status \< 3
* Bone and/or lymph node metastases based on conventional (CT and bone scan) or metabolic imaging
* Bone and/or lymph node metastases suitable for SRT, according to the investigator
* Adequate organ function:

  1. Absolute Neutrophil Count (ANC) ≥ 1000/mm3 or
  2. Platelet Count ≥ 50 000/mm3 or
  3. Haemoglobin ≥ 8 g/dL (allowing transfusion or other intervention to achieve this minimum haemoglobin)
* Age ≥ 18 years at time of study entry
* Written informed consent obtained from the patient prior to performing any protocol-related
* Patient is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.
* Patient has valid health insurance
* Life time expected \> 3 months

Exclusion Criteria:

* Evidence of symptomatic metastases to the lungs, brain, peritoneum or liver
* Evidence of diffuse metastatic spread to the bone marrow (e.g. positive super bone scan) or the cerebral spinal fluid as per bone scan (no lumbar puncture required).
* Evidence of presence of symptomatic spinal cord compression with indication of neurosurgical decompression.
* Patient with symptomatic and/or high-risk tumor volume-to-bone marrow reserve ratio \> 50%
* Concurrent enrolment in another clinical study, unless it is a non-therapeutic clinical study
* Mental impairment (psychiatric illness/social situations) that may compromise the ability of the patient to give informed consent and comply with the requirements of the study;
* Patient who has forfeited his/her freedom by administrative or legal award or who is under guardianship;
* Patients unable to undergo medical follow-up in the study for geographical, social or psychological reasons.
* History of another primary malignancy except for

  1. Malignancy treated with curative intent and with no known active disease ≥2 years before the first dose of SRT and of low potential risk for recurrence
  2. Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease
  3. Adequately treated carcinoma in situ without evidence of disease
* Uncontrolled pain that contraindicates patient positioning on the radiotherapy table according to investigator
* Patient indicated to or currently treated by cytopenic treatment as chemotherapy or RadioLigand Therapy
* Patient under concomitant treatment that may generate severe gastro-intestinal disorder or genito-urinary disorder