Clinical trial · Observational
Endocrine Disruptors, Toxic and Essential Chemical Elements and Polycystic Ovary Syndrome
The Association of Endocrine Disruptors and Toxic and Essential Chemical Elements With Polycystic Ovary Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Studies have shown that endocrine disruptors (EDs) and toxic and essential chemical elements affect women's reproductive health and may play a role in the development of polycystic ovary syndrome (PCOS). There is little research examining the association of EDs and toxic and essential chemical elements with PCOS, and for some chemical compounds there is none. In our study, we will examine the relationship of EDs (bisphenols, parabens, triclosan) and toxic (cadmium-Cd, lead-Pb, mercury-Hg, arsenic-As) and essential chemical elements (selenium-Se, copper-Cu, zinc-Zn, manganum-Mn, molibdenum-Mo) in biological samples (blood, urine) of women with PCOS. Main hypothesis is that the levels of EDs, toxic chemical elements and molibdenum-Mo in the biological samples of PCOS women will be higher, and the levels of essential chemical elements will be lower than in the control group and related to the altered liver and kidney function and to the women's lifestyle and the environment they live in.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| parabens | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- PCOS study group
- description
- PCOS patients aged 20 to 39 years
- interventionNames
- Other: parabens
- label
- healthy control group
- description
- Healthy women aged 20 to 39 years
- interventionNames
- Other: parabens
Primary outcomes (1)
- measure
- Levels of EDs, toxic and essential chemical elements in biological samples (blood, urine)
- timeFrame
- 1 month
- description
- blood and urine levels
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 39 Years
Show eligibility criteria text
Inclusion Criteria: * body mass index (BMI) between 18.5 and 29.9 kg/m2 * fulfilling two of the three Rotterdam diagnostic criteria for the diagnosis of PCOS: oligo- or anovulation, ultrasound-visible morphological picture of PCO (presence of 12 or more follicles of size 2-9 mm in one of the ovaries) and/or clinical/biochemical signs of hyperandrogenism (study group) * a regular menstrual cycle of 21 to 35 days (control group) Exclusion Criteria: * pregnancy * hormonal treatment in the last 3 months (hormonal contraception, hormone replacement therapy, progestogens) * hyperprolactinemia * hypothyroidism, hyperthyroidism * known premature ovarian failure, primary amenorrhea * chronic diseases: diabetes, depression, Crohn's disease, celiac disease, cardiovascular diseases, liver and kidney disease, asthma, chronic obstructive pulmonary disease, diseases of the musculoskeletal system, neurological diseases, oncological diseases.
References
Publications (4)
- BACKGROUNDRattan S, Zhou C, Chiang C, Mahalingam S, Brehm E, Flaws JA. Exposure to endocrine disruptors during adulthood: consequences for female fertility. J Endocrinol. 2017 Jun;233(3):R109-R129. doi: 10.1530/JOE-17-0023. Epub 2017 Mar 29. PMID 28356401
- BACKGROUNDYilmaz B, Terekeci H, Sandal S, Kelestimur F. Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention. Rev Endocr Metab Disord. 2020 Mar;21(1):127-147. doi: 10.1007/s11154-019-09521-z. PMID 31792807
- BACKGROUNDChiang C, Mahalingam S, Flaws JA. Environmental Contaminants Affecting Fertility and Somatic Health. Semin Reprod Med. 2017 May;35(3):241-249. doi: 10.1055/s-0037-1603569. Epub 2017 Jun 28. PMID 28658707
- BACKGROUNDYe J, Zhu W, Liu H, Mao Y, Jin F, Zhang J. Environmental exposure to triclosan and polycystic ovary syndrome: a cross-sectional study in China. BMJ Open. 2018 Oct 17;8(10):e019707. doi: 10.1136/bmjopen-2017-019707. PMID 30337305