Clinical trial · Observational
Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics
Changes in Cerebral Blood Flow Before and After Prone Position in Patients With ARDS Predict the Occurrence of Neurological Complications
NCT06967285CI-TRIAL-00089565PRONEBRAINARrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| ARDS (Moderate or Severe) | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Prone ventilation | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Neuroimaging Studies
- timeFrame
- From enrollment to 2 weeks after the end of treatment.
- description
- Cranial CT or MRI Scans Conducted Before and After Prone Positioning to Detect New-Onset Neurological Complications Such as Cerebral Edema, Intracranial Hemorrhage, and Cerebral Infarction
- measure
- Biomarker Detection
- timeFrame
- From enrollment to 2 weeks after the end of treatment.
- description
- Blood samples were collected for NSE(Neuron-specific Enolase)and IL-6(Interleukin-6)before and after prone positioning.
Secondary outcomes (2)
- measure
- Incidence rate of delirium
- timeFrame
- From enrollment to 2 weeks after the end of treatment.
- description
- Assessment using the Confusion Assessment Method for the Intensive Care Unit(CAM-ICU)was conducted before and after prone position therapy in patients.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age≥18 years * Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂\<150 mmHg,and requiring prone ventilation * Expected duration of mechanical ventilation\>48 hours * Written informed consent obtained Exclusion Criteria: * Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension) * Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics * Life-threatening ARDS * Patients who are unable to undergo neurological assessment * Poor image quality or absence of images
References
Publications (0)
Data not yet available
No reference posted for this study.