Clinical trial · Interventional
Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study
Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Diagnosis of extrahepatic cholangiocarcinoma is challenging because the yield of imaging and tissue sampling is limited. Raman spectroscopy is an optical method based on the analysis of scattered monochromatic light. Raman spectroscopy is able to provide a molecular 'fingerprint' of the tissue to determine its type. The aim of this pilot study was to develop a methodology for in vivo Raman spectroscopy in bile ducts to improve the current diagnostic capabilities of extrahepatic cholangiocarcinoma.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Biliary Stricture | — | UNRESOLVED | — |
| Cholangiocarcinoma, Extrahepatic | Extrahepatic Cholangiocarcinoma | ONTOLOGY_EXACT | 0.98 |
| Cholangiocarcinoma of the Extrahepatic Bile Duct | — | UNRESOLVED | — |
| Cholangiocarcinoma, Perihilar | Cholangiocarcinoma | ONTOLOGY_EXACT | 0.85 |
| Diagnosis | — | UNRESOLVED | — |
| Endoscopy | — | UNRESOLVED | — |
| Klatskin Tumor | Hilar Cholangiocarcinoma | ALIAS | 0.90 |
| Malignant Biliary Stricture | — | UNRESOLVED | — |
| Raman Spectroscopy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endoscopic retrograde cholangiopancreatography (ERCP) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- patients with extrahepatic cholangiocarcinoma
- description
- 20 patients with known cholangiocarcinoma indicated for endoscopic retrograde cholangiopancreatography over 18 years of age
- interventionNames
- Procedure: Endoscopic retrograde cholangiopancreatography (ERCP)
Primary outcomes (1)
- measure
- The differences in Raman spectra of malignant biliary tissue compared to healthy biliary tissue
- timeFrame
- Perioperative/Periprocedural
- description
- During single ERCP procedure, we take 20 measurements of the Raman spectra (10 from malignant biliary tissue and 10 from healthy biliary tissue) that each tissue emits after interaction with the laser light. We are interested in the specific difference in the spectra of each tissue, which will be shown as a two-dimensional curve. The differences in the spectra of each tissue will be reflected by a change in the shape of the curve.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * person older than 18 years, who has known extrahepatic cholangiocarcinoma and is indicated for ERCP Exclusion Criteria: * disagreement with the study
References
Publications (1)
- BACKGROUNDSlodicka P, Falt P, Ranc V, Zoundjiekpon VD, Urban O. Raman spectroscopy in the diagnosis of malignant biliary stricture: A feasibility study. Hepatobiliary Pancreat Dis Int. 2025 Apr;24(2):211-216. doi: 10.1016/j.hbpd.2024.11.003. Epub 2024 Nov 16. No abstract available. PMID 39603958