Clinical trial · Observational
Evaluation of Alternative Transfusion Triggers in Hemodynamically Stable, Non-Ventilated Cancer Patients
Evaluation of Alternative Transfusion Triggers in Hemodynamically Stable, Non-Ventilated Cancer Patients: A Prospective Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective, single-center observational study conducted at the Kazakh Institute of Oncology and Radiology. The study included 107 clinically stable adult patients with cancer who required red blood cell transfusion based on a restrictive hemoglobin threshold. The aim of the study was to evaluate alternative physiological indicators of transfusion need and effectiveness. Measurements included oxygen extraction ratio (O₂ER), central venous oxygen saturation (ScvO₂), partial pressure of oxygen in central venous blood (PvO₂), arterio-venous oxygen difference (A-VO₂diff), lactate, and veno-arterial carbon dioxide difference (ΔCO₂). These parameters were assessed before and one hour after transfusion. For data analysis, patients were stratified into two groups based on their baseline O₂ER (≤35.4% and \>35.4%) to evaluate whether higher O₂ER is associated with more pronounced physiological response to transfusion.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Alternative Physiological Transfusion Triggers | — | UNRESOLVED | — |
| Anemia | — | UNRESOLVED | — |
| Blood Transfusion | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Hemoglobin | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Red blood cell transfusion | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Cancer Patients with Anemia Receiving RBC Transfusion
- description
- This group includes clinically stable, non-ventilated adult oncology patients with anemia who received red blood cell transfusion at the Kazakh Institute of Oncology and Radiology. All participants were monitored for physiological parameters-including O₂ER, ScvO₂, PvO₂, A-VO₂diff, lactate, and ΔCO₂-before and one hour after transfusion.
- interventionNames
- Procedure: Red blood cell transfusion
Primary outcomes (1)
- measure
- Change in Oxygen Extraction Ratio (O₂ER)
- timeFrame
- Baseline and 1 hour post-transfusion
- description
- Difference in oxygen extraction ratio measured before and one hour after red blood cell transfusion
Secondary outcomes (5)
- measure
- Change in Partial Pressure of Oxygen in Central Venous Blood (PvO₂)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult cancer patients (age 18 years or older) * Hemodynamically stable * Not requiring any form of respiratory support * Presence of a central venous catheter inserted into the superior vena cava Exclusion Criteria: * Hemodynamic instability requiring inotropic or vasopressor support * Active bleeding * Shock of any etiology * Patient refusal to participate in the study * Hematological malignancies * Age under 18 years * Pregnancy
References
Publications (1)
- DERIVEDArynov A, Gratz J, Kabon B, Kaidarova D, Satanova A, Brotfain E. Evaluation of alternative transfusion triggers in hemodynamically stable, non-ventilated cancer patients: a prospective observational study. Sci Rep. 2025 Dec 19;16(1):2831. doi: 10.1038/s41598-025-32630-6. PMID 41419638