Clinical trial · Interventional
Repetitive Transcranial Magnetic Stimulation in Cancer Pain Management
Feasibility and Effectiveness of Repetitive Transcranial Magnetic Stimulation in Patients With Cancer Pain
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Over half of cancer patients experience cancer-related pain. Despite advances in pain management with opioids, many patients continue to suffer from chronic cancer pain. The underlying mechanisms of cancer-related pain remain poorly understood, but they may be linked to brain neuroplasticity. As a result, some researchers suggest that targeting the motor cortex in cancer patients could improve pain management. However, few studies have investigated the effectiveness of remodeling neuroplasticity with repetitive transcranial magnetic stimulation (rTMS) to reduce cancer-related pain. To validate the use of rTMS in cancer-related pain, we plan to conduct a randomized controlled trial involving 30 cancer pain patients. Participants will be randomly assigned to receive either rTMS or sham rTMS treatment. Functional magnetic resonance imaging (fMRI) and pain index assessments will be conducted before and after the treatment to evaluate the outcomes.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Pain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Repetitive transcranial magnetic stimulation (rTMS) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Repetitive transcranial magnetic stimulation
- interventionNames
- Device: Repetitive transcranial magnetic stimulation (rTMS)
- type
- SHAM_COMPARATOR
- label
- Sham Repetitive transcranial magnetic stimulation
- interventionNames
- Device: Repetitive transcranial magnetic stimulation (rTMS)
Primary outcomes (2)
- measure
- Brief Pain Inventory, BPI
- timeFrame
- Assess the BPI outcome before the intervention, after 1 week and 2 weeks of intervention, as well as 1 week and 4 weeks after the intervention is completed.
- description
- BPI is to assess the severity of pain and the impact of pain on daily functions, including Severity of pain, impact of pain on daily function, location of pain, pain medications and amount of pain relief in the past 24 hours.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients have cancer pain symptoms, confirmed by a physician as cancer pain or neuropathic cancer pain 2. Experienced the worst pain NRS score ≥ 4 3. The patient demonstrate good cognition and is able to cooperate with the assessment of pain severity. 4. The estimated survival time exceeds 3 months. 5. Pre-existing bisphosphonate, chemotherapy, and hormonal therapy regimens remained unchanged throughout the study. Exclusion Criteria: 1. Individuals who have undergone head surgery or have metal implants in the head. 2. Individuals with implanted cardiac pacemakers or cochlear prostheses. 3. Have a history of epilepsy. 4. Patients diagnosed with primary brain tumors or metastatic brain lesions. 5. Present with additional neurological, psychiatric, or severe medical disorders. 6. Individuals with metallic implants located in the cranial or cervical regions. 7. Women who are pregnant. 8. Presence of acute pain in any body region attributable to other medical conditions. -
References
Publications (0)
Data not yet available