Clinical trial · Observational
Exploration of Risk Factors for Postoperative Cerebral Infarction in Lung Cancer Patients: a Retrospective Single-centre Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Lung cancer remains the world's leading cancer in terms of morbidity and mortality, with more than 20 million new cases and 9.7 million deaths annually. Despite improvements in surgical techniques and medical care, the number of elderly people undergoing surgery is gradually increasing, so there are an increasing number of complications following lung resection. Postoperative cerebral infarction is a relatively rare but devastating complication that places a heavy burden on patients and families. The incidence of postoperative cerebral infarction in patients after thoracic surgery has been reported to be 0.6-1.1%. There is a risk of postoperative cerebral infarction after lung cancer surgery, and the results of a few studies have shown that postoperative cerebral infarction is related to old age, male, hypertension, hyperlipidemia, and lobectomy factors, but the pathogenesis of the occurrence of cerebral infarction has not been clearly proved for the time being, and so these risk factors cannot be taken as the direct cause of cerebral infarction. Therefore, we need to further explore the factors leading to cerebral infarction after lung cancer surgery. If we can further prove that some of the risk factors are related to the causes of cerebral infarction after lung cancer surgery, we can make corresponding strategies in the perioperative period to improve the safety of surgery and reduce the incidence of cerebral infarction in the postoperative period.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer, Non-Small Cell | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
| Postoperative Cerebral Infarction | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| non-intervention | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Postoperative cerebral infarction
- interventionNames
- Other: non-intervention
- label
- No postoperative cerebral infarction
- interventionNames
- Other: non-intervention
Primary outcomes (1)
- measure
- Analysing independent risk factors for cerebral infarction after pneumonectomy
- timeFrame
- 5min
- description
- Clinical trial data were entered into Excel for recording information and subsequently converted to SPSS for statistical analysis. Descriptive statistics of the named data were expressed as absolute numbers and percentages according to each patient. Clinical characteristics of patients who developed cerebral infarction after surgery were retrospectively compared with those of patients who underwent pneumonectomy without cerebral infarction. Continuous data were expressed as median and interquartile range, and categorical data were expressed as frequencies and percentages. Independent risk factors for developing cerebral infarction after pneumonectomy were analysed using univariate and multivariate logistic regression.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: Postoperative cerebral infarction Exclusion Criteria: No postoperative infarction
References
Publications (5)
- BACKGROUNDNishizawa N, Okawara M, Mori M, Fujino Y, Matsuda S, Fushimi K, Tanaka F. Postoperative cerebral infarction risk is related to lobectomy site in lung cancer: a retrospective cohort study of nationwide data in Japan. BMJ Open Respir Res. 2022 Jul;9(1):e001327. doi: 10.1136/bmjresp-2022-001327. PMID 35868837
- BACKGROUNDMatsumoto K, Sato S, Okumura M, Niwa H, Hida Y, Kaga K, Date H, Nakajima J, Usuda J, Suzuki M, Souma T, Tsuchida M, Miyata Y, Nagayasu T. Frequency of cerebral infarction after pulmonary resection: a multicenter, retrospective study in Japan. Surg Today. 2018 May;48(5):571-572. doi: 10.1007/s00595-017-1620-9. Epub 2018 Jan 11. No abstract available. PMID 29327086
- BACKGROUNDGao S, Zhou Y, Yang R, Du C, Wu Y. Risk factors for postoperative cerebral infarction in patients after lung resection: a single-center case-control study. J Thorac Dis. 2023 Feb 28;15(2):376-385. doi: 10.21037/jtd-22-1019. Epub 2023 Jan 16. PMID 36910048
- BACKGROUNDHattori A, Takamochi K, Kitamura Y, Matsunaga T, Suzuki K, Oh S, Suzuki K. Risk factor analysis of cerebral infarction and clinicopathological characteristics of left upper pulmonary vein stump thrombus after lobectomy. Gen Thorac Cardiovasc Surg. 2019 Feb;67(2):247-253. doi: 10.1007/s11748-018-1017-8. Epub 2018 Sep 24. PMID 30251002
- BACKGROUNDNojiri T, Inoue M, Takeuchi Y, Maeda H, Shintani Y, Sawabata N, Hamasaki T, Okumura M. Impact of cardiopulmonary complications of lung cancer surgery on long-term outcomes. Surg Today. 2015 Jun;45(6):740-5. doi: 10.1007/s00595-014-1032-z. Epub 2014 Sep 19. PMID 25236860