Clinical trial · Observational
Dutch Registry of Pediatric Cardiac Arrest
Pediatric Resuscitation Neuroprognostication and Outcomes Registry
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to understand the long-term outcomes of children in the Netherlands who experience cardiac arrest, either in or outside of the hospital. The main questions it aims to answer are: What are the survival rates and neurological outcomes in children after cardiac arrest? What types of emergency and post-resuscitation care are provided, and how do they impact long-term recovery? How do children and their families function over time after the event? Researchers will analyze data from routine medical records and follow patients through standard outpatient visits. No extra procedures will be required beyond normal care. For those who survive to hospital discharge, additional follow-up data will be collected with consent. Participants will: Be children under 18 years old who have had a cardiac arrest and were treated in one of the seven participating academic hospitals Have their routine medical care data collected anonymously Be invited (if surviving) for follow-up visits at 3, 12, and 24 months post-arrest and at specific ages (5, 8, 12, and 17 years) to assess physical and psychological recovery
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiac Arrest (CA) | Malignant Neoplasm | ALIAS | 0.85 |
| Pediatric ALL | Childhood Acute Lymphoblastic Leukemia | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Pediatric cardiac arrest patient
- description
- The study cohort consists of pediatric patients under the age of 18 who have experienced a cardiac arrest-either in-hospital (IHCA) or out-of-hospital (OHCA)-in the Netherlands. Eligible patients must have received care from emergency medical services (EMS) or been admitted to one of the seven participating academic pediatric hospitals following the arrest. Cardiac arrest is defined as the absence of a palpable pulse or the need for chest compressions lasting at least one minute, in line with European Resuscitation Council guidelines. Both basic life support (BLS) and advanced pediatric life support (APLS) protocols apply.
Primary outcomes (7)
- measure
- Long-term Neurological Outcome (PCPC)
- timeFrame
- At 3, 12, and 24 months post-cardiac arrest; and at ages 8, 12, and 17 years, depending on age at event
- description
- Neurological outcome will be assessed using the Pediatric Cerebral Performance Category (PCPC) scale, a validated functional outcome measure ranging from 1 to 6. A score of 1 indicates normal age-appropriate cerebral performance, while higher scores reflect increasing levels of neurological impairment: mild (2), moderate (3), severe (4), coma or vegetative state (5), and death (6). Lower scores indicate better neurological function. The highest available follow-up score will be used as the primary neurological outcome measure.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 24 Hours
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Pediatric patients under the age of 18 * Experienced in-hospital or out-of-hospital cardiac arrest in the Netherlands * Attended by emergency medical services or admitted to one of the seven participating Dutch academic pediatric hospitals * Cardiac arrest defined as absence of palpable pulse or need for chest compressions lasting ≥1 minute * Arrest managed under European Resuscitation Council guidelines (BLS/APLS) Exclusion Criteria: * Cardiac arrest occurring in neonates younger than 24 hours of age * Cardiac arrest occurring in a neonatal intensive care unit (NICU) setting
References
Publications (1)
- DERIVEDAlbrecht M, Hunfeld M, Arkesteijn-Muit A, Dulfer K, de Hoog M, de Jong G, de Jonge R, Lamore A, Nadkarni V, Buysse C; PROGNOSE Group Collaborative Investigators. A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up - towards an international prognostication guideline. Resusc Plus. 2025 May 9;24:100976. doi: 10.1016/j.resplu.2025.100976. eCollection 2025 Jul. PMID 40491775