Clinical trial · Observational
Rate of Malignant Transformation and Clinical Characteristics Among an Oral Lichen Planus Cohort: a Retrospective Center Experience
Observational Study of an OLP Patients Cohort: Characteristics, Comorbidities, Risk Factors for Malignant Transformation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main objective of this paper will be to evaluate the rate of malignant transformation among a cohort of patients affected by oral lichen planus with long-term follow-up. Secondary aims will be to study and describe the characteristics of these patients to identify potential risk factors for malignant transformation, and to evaluate the therapeutic effects and features to OLP drgus.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Carcinoma | Lip and Oral Cavity Carcinoma | ALIAS | 0.90 |
| Oral Carcinoma in Situ | — | UNRESOLVED | — |
| Oral Lichen Planus | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- A cohort of patients affected by Oral lichen patients
- description
- A cohort of patients affected by Oral lichen patients will be evaluated retrospectively in anamnestic and clinical characteristics in order to assess any risk factors for malignant transformation. Also, dental and periodontal status will be evaluated based on charts and charting data.
Primary outcomes (1)
- measure
- Number of Oral Carcinomas
- timeFrame
- From January 2024 to January 2028
- description
- Number of cases that will be histologically diagnosed as Oral Carcinomas. This outcome will be expressed as a dichotomous variable (i.e., yes/no).
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Clinical-histological diagnosis of Oral lichen planus * Patients who gave consensus to personal data treatment * Minimum 6 months follow-up Exclusion Criteria: * Patients who did not give consensus to personal data treatment * Oral lichenoid lesions * Patients with anamnesis of hematopoietic stem cells transplant * Patients with a OSCC at the first histological examination (i.e., namely: also OSCC patients with a OLP background were excluded)
References
Publications (0)
Data not yet available