Clinical trial · Interventional
Cancer-related Fatigue and Symptom Clusters - Effects of Virtual, Imagined and Real-life Nature-based Therapy in Cancer Survivors
Cancer-related Fatigue and Symptom Clusters - Effects of Virtual, Imagined and Real-life Nature-based Therapy in Cancer Survivors - a RCT
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a randomized, controlled, bicenter trial comparing the effects on symptoms and quality of life in cancer survivors. Three nature-based therapies will be compared with a wait-list group. The therapies are: virtual reality simulated forest, guided imaging and classic forest bathing. Each intervention lasts 30 minutes and takes place once a week for 8 weeks. All interventions involve different stimulus types: visual, olfactory, auditory and tactile.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Survivors | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Imaging FOREST bathing | Other | — | UNRESOLVED |
| Real-life forest bathing | Other | — | UNRESOLVED |
| Simulated FOREST bathing (Virtual Reality) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Real-life FOREST bathing
- interventionNames
- Other: Real-life forest bathing
- type
- EXPERIMENTAL
- label
- Simulated FOREST bathing (Virtual Reality).
- interventionNames
- Other: Simulated FOREST bathing (Virtual Reality)
- type
- EXPERIMENTAL
- label
- Imaging FOREST bathing.
- interventionNames
- Other: Imaging FOREST bathing
- type
- NO_INTERVENTION
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria:
* Patients who have completed treatment for cancer (\*with the exception of long-term adjuvant endocrine therapy).
* Subjective Impairment due to Cancer-Related Fatigue (CrF) . NCCN-recommended questions are used for screening ("How exhausted do you feel on a scale of 0 to 10?" and "How impaired do you feel by this fatigue on a scale of 0 to 10?" (threshold \>4 on either scale).
* At the time of study inclusion, it must be expected that no further antitumor therapy measures will be started within the next 6 months.
* Patients must be able to refrain from smoking up to 15 minutes before the intervention (smoking within 15 minutes before therapy impairs the participant's ability to perceive the aroma of the phytoncides).
* Written and valid informed consent from the patient.
Exclusion Criteria:
* Presence of inadequately controlled major depression in the opinion of the investigator.
* Asthma (inhaled phytoncides may cause airway irritation, exacerbation of asthma, or bronchoconstriction).
* Known allergy to pine or citrus fragrance.
* Anosmie.
* Medical history of seasickness (virtual reality can cause nausea/vomiting with no improvement after 5-10 minutes).
* History of seizures (virtual reality may increase susceptibility to seizures due to the changing light in the forest video).
* Visual and hearing impairments that are not corrected by visual or hearing aids.
* Unwillingness to store and share personal medical data as part of the protocol.
* Participation in another clinical trial focusing on behavioural or complementary medicine interventions.
* Missing or incomplete consent form.References
Publications (0)
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