Clinical trial · Interventional
Using Xe MRI to Guide Radiation Therapy for Lung Cancer
Image-Based Functionally Adapted Radiation Therapy for Lung Cancer
NCT06925295CI-TRIAL-00100001(XeRTLC)recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Imaging Techniques | — | UNRESOLVED | — |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood Biomarkers | Diagnostic Test | — | UNRESOLVED |
| Medical Research Council Dyspnea score | Other | — | UNRESOLVED |
| Pulmonary Function Testing | Diagnostic Test | — | UNRESOLVED |
| Quality of Life Questionnaire | Other | — | UNRESOLVED |
| St. George's Respiratory Questionnaire | Other | — | UNRESOLVED |
| Xenon MRI | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Technical Development Arm
- description
- Lung cancer patients who will undergo standard-of-care stereotactic body radiation therapy (SBRT).
- interventionNames
- Drug: Xenon MRI
- Diagnostic Test: Pulmonary Function Testing
- Other: Quality of Life Questionnaire
- Other: Medical Research Council Dyspnea score
- Other: St. George's Respiratory Questionnaire
- Diagnostic Test: Blood Biomarkers
- type
- EXPERIMENTAL
- label
- Implementation Arm
- description
- Lung cancer patients who will undergo SBRT plans that were functionally adapted to avoid highly functioning lung based on Xe MRI.
- interventionNames
- Drug: Xenon MRI
- Diagnostic Test: Pulmonary Function Testing
- Other: Quality of Life Questionnaire
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial 1. Aged 18-80 years 2. Willing and able to provide informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.) 3. Clinical diagnosis of lung cancer made by a board-certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease with the exception of the below criteria Exclusion Criteria: Subjects presenting with any of the following will not be included in the trial: 1. Subject is less than 18 years old or incarcerated 2. MRI is contraindicated based on responses to MRI screening questionnaire 3. Subject is pregnant or lactating 4. Resting oxygen saturation \<90% on supplemental oxygen 5. Respiratory illness of bacterial or viral etiology within 30 days of planned treatment 6. Subject has history of any known ventricular cardiac arrhythmia 7. Subject has history of cardiac arrest within the last year 8. Subject has prior history of cancer treatment with radiation therapy to the lung 9. Subject has concurrent cancer treatment with agents associated with increased risk of radiation pneumonitis (e.g. immunotherapy, chemotherapy) 10. Subject does not fit into 129Xe vest coil used for MRI 11. Subject cannot hold his/her breath for 15 seconds 12. Subject deemed unlikely to be able to comply with instructions during imaging 13. Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements
References
Publications (0)
Data not yet available
No reference posted for this study.