Clinical trial · Observational
Thyroid Cancer in Surgical Treated Multinodular Goiter
Thyroid Cancer in Surgically Treated Multinodular Goiter: Incidence and Histopatological Outcomes
NCT06924242CI-TRIAL-00088477completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in MNG. It seeks to contribute to optimizing diagnostic evaluations for patients with multinodular goiter.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Goiter, Nodular | — | UNRESOLVED | — |
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Total Thyroidectomy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| total or partial thyroidectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patient with multinodular goiter who underwent total or partial thyroidectomy
- interventionNames
- Procedure: total or partial thyroidectomy
Primary outcomes (1)
- measure
- incidence of occult thyroid carcinoma
- timeFrame
- 6 years
- description
- Incidence of occult thyroid carcinoma in a cohort of patients with multinodular goiter, providing new insights into the prevalence and characteristics of thyroid malignancies.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * patients diagnosed with multinodular goiter via thyroid ultrasound, with or without FNA cytology. * patients who underwent surgery. * availability of complete clinical data Exclusion Criteria: * history of thyroid carcinoma or other thyroid neoplasms. * not completed postoperative follow up. * patients with preoperative FNA results indicating malignancy (TIR 4-5), suspicion of malignancy (TIR 3), or indeterminate significance (TIR 1)
References
Publications (1)
- DERIVEDPavone G, Lamanna E, Pacilli M, Khoury E, Ambrosi A, Tartaglia N. Incidental thyroid carcinoma in surgically treated multinodular goiter: a retrospective study. Front Surg. 2026 Jul 2;13:1825352. doi: 10.3389/fsurg.2026.1825352. eCollection 2026. PMID 42465863