Effect of Biejia-Ruangan Compound on Survival Rate and Recurrence Rate of Hepatocellular Carcinoma After Radical Treatment

Inclusion Criteria:

* Age range: 18-75 years old (including 18 and 75 years old), regardless of gender.
* Individuals with chronic hepatitis B liver fibrosis or cirrhosis.
* According to the "Diagnosis and Treatment Guidelines for Primary Liver Cancer" (2024 edition) liver cancer diagnosis roadmap, the first clinical diagnosis is Hepatocellular carcinoma(HCC).
* The staging of liver cancer is CNLC stage Ia - IIa.
* Radical treatment has been completed, with surgical resection or local ablation.
* 8-12 weeks after radical surgery, imaging and serological evaluations showed no residual cancerous lesions and no new cancerous lesions were found.
* Child Pugh score A/B.
* Voluntarily joining the group, able to understand and sign an informed consent form.

Exclusion Criteria:

* Pregnant and lactating women;
* Prior to radical liver cancer surgery, the patient had received radiation, chemotherapy, molecular targeting, immunotherapy, and other anti-tumor treatments;
* Receive other anti-tumor Chinese medicine (including traditional Chinese patent medicines and simple preparations or Chinese herbal medicine);
* Individuals with mental illnesses, especially those with a history of depression, anxiety, mania, schizophrenia, or a family history of mental illness (especially those with a history of depression or tendencies towards depression);
* Combination of hepatitis A, C, D, E, and/or current HIV infections;
* Kidney diseases: acute and chronic nephritis, renal insufficiency, nephrotic syndrome, etc., or screening with blood creatinine\>2.0 × ULN;
* Autoimmune diseases, including psoriasis, systemic lupus erythematosus, autoimmune liver disease, etc;
* Patients who experience upper gastrointestinal bleeding within the first 3 months (including the screening period) prior to screening;
* Individuals with a serious history of heart disease, especially those with unstable or poorly controlled heart disease within the past 6 months;
* Individuals who plan to receive organ transplantation or have already undergone organ transplantation;
* Those who are allergic to Compound Biejia Ruangan Tablets, nucleoside (acid) analogues, or drug excipients, or who meet any contraindications in the experimental drug instructions;
* Have used other anti fibrotic drugs within the first 6 months of enrollment, such as Fuzheng Huayu, Anluo Huaxian, and Ganshuang Granules.
* Other situations where the participant has participated in other intervention trials within the previous month or where the researcher deems it unsuitable for inclusion.