Clinical trial · Interventional
Processed EEG for Monitoring of Anesthetic Depth in Intracranial Tumor Surgery
Anesthetic Depth Assessed by Processed EEG (pEEG) - a Comparison of Manual Total Intravenous Anesthesia and Target Controlled Anesthesia in Tumor Resection Via Craniotomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
An important feature of neurosurgical anesthesia is early postoperative recovery of consciousness with minimal residual sedation. This is a key factor to enable early neurological assessment and early discovery of postoperative complications. The goal of this single centre clinical trial is to compare propofol/remifentanil anesthesia delivered by manual total intravenous anesthesia (mTIVA) or target controlled infusion (TCI) for intracranial tumor resection via craniotomy. Anesthetic depth will be assessed by a simplified processed EEG (pEEG). The main question is time spent within recommended pEEG- levels from anesthesia induction until end of surgery. Secondary questions are: * mean pEEG-level, time from end of surgery to consiousness, * peroperative propofol/remifentanil consumption * postoperative degree of sleepiness * awareness assessment Participants are adults having have planned surgery for open resection of a brain tumor and will receive general anesthesia with propofol and remifentanil randomized to mTIVA or TCI. pEEG vill be blinded. * Participants will be asked to grade postoperative sleepiness using a specific scale * Follow up regarding awareness will be performed.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor Adult | Brain Neoplasm | ALIAS | 0.85 |
| Processed EEG | — | UNRESOLVED | — |
| Total Intravenous Anesthesia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| depth of anesthesia | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- TIVA
- description
- propofol and remifentanil anesthesia using traditional total intravenous anestesia (mg/kg/min)
- interventionNames
- Device: depth of anesthesia
- type
- ACTIVE_COMPARATOR
- label
- TCI
- description
- Propofol and remifentanil anestesia using target controlled anestesia
- interventionNames
- Device: depth of anesthesia
Primary outcomes (1)
- measure
- Amount of time during anestehsia and surgery within recommended levels of processed EEG (pEEG)
- timeFrame
- During anesthesia
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Elective craniotomy for tumor resection * Adult patient * Consent to participation Exclusion Criteria: * Cognitive impact affecting infrmed consent * brain tumor planned for biopsy without resection Tumor localisation not permitting placement of pEEG electrodes.
References
Publications (0)
Data not yet available