Clinical trial · Observational
Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this retrospective study is to evaluate the long-term clinical outcomes and complications associated with amygdalo-hippocampectomy using the surgical technique developed by Pr. Coubes (Montpellier, FRANCE). The main questions it aims to answer are: * What are the complications and evolution of clinical outcomes in patients treated with this technique for hippocampal sclerosis or other intern temporal diseases ? * What variables are associated with better seizure control following surgery? Participants include 234 patients treated over the last 30 years at the CHU de Montpellier, FRANCE. The study will analyze clinical data, including seizure outcomes based on ILAE criteria, post-operative complications, and factors influencing recovery and reintegration into daily life.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cavernoma | Cavernous Hemangioma | ALIAS | 0.90 |
| Cortical Dysplasia | — | UNRESOLVED | — |
| DGONC | Diffuse Glioneuronal Tumor with Oligodendroglioma-Like Features and Nuclear Clusters | ALIAS | 0.90 |
| Dysembryoplastic Neuroepithelial Tumor | Dysembryoplastic Neuroepithelial Tumor | ONTOLOGY_EXACT | 0.98 |
| Epidermal Cyst | — | UNRESOLVED | — |
| Ganglioglioma | Ganglioglioma | ONTOLOGY_EXACT | 0.90 |
| Hamartoma | — | UNRESOLVED | — |
| Hippocampal Sclerosis | — | UNRESOLVED |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Amygdalo-Hippocampectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients operated
- description
- We studied all the patients who underwent an Amygdalo-Hippocampectomy in the University Hospital of Montpellier, France from 1995 until 2022
- interventionNames
- Procedure: Amygdalo-Hippocampectomy
Primary outcomes (1)
- measure
- Post-Surgical Classification assessing epilepsy's control
- timeFrame
- From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to twenty years. The study starts in 2024 and ends in 2025, which lasts one year.
- description
- The ILAE post-surgical classification system is used to categorize seizure outcomes after epilepsy surgery. It provides a standardized way to evaluate how effectively surgery controls seizures, enabling consistency in reporting and comparison of surgical outcomes across studies and clinical settings. In those cases of drug-resistance epilepsy, we will assess the epilepsy's control after the surgery. 1. Completely seizure free; no auras 2. Only auras; no other seizures 3. One to three seizure days per year 4. Four to 12 seizure days per year 5. Daily seizures 6. More than 100% increase of baseline ; auras
Secondary outcomes (5)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients who had undergone an Amygdalo-Hippocampectomy according to the surgical procedure that we describe Exclusion Criteria: * Patients who did not have this exact procedure.
References
Publications (0)
Data not yet available