Clinical trial · Observational
Infectious Complications After Esophagectomy
Infectious Complications, Associated Factors, and Prognosis After Esophagectomy for Cancer: A French, Multicenter, Retrospective Study - CIFO-study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260915-000001
Summary
Brief summary (as posted)
Infectious complications represent the most common postoperative adverse events following esophagectomy for cancer, such as pneumonia (15% of cases). These complications increase immediate risks, lengthen hospital stays, and worsen patient quality of life. The population includes patients admitted to intensive care after esophagectomy for cancer between January 1, 2017, and December 31, 2024. The study focuses on this population due to the increasing incidence of esophageal cancer, the increased use of surgery for these indications, and the importance of postoperative infections in these complex procedures, despite their understudied nature in the current literature. Identifying modifiable risk factors could lead to corrective measures and thus improve the prognosis of postoperative patients. The research focuses primarily on the incidence, types, factors, and prognosis associated with the occurrence of infections after esophagectomy for cancer. It also includes an analysis of the pathogens involved, their resistance profiles, and the antibiotic therapies used in first-line probabilistic treatment.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophagectomy | — | UNRESOLVED | — |
| Infections | — | UNRESOLVED | — |
| Pneumonia | — | UNRESOLVED | — |
| Postoperative Complications | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Incidence of infections after esophagectomy for cancer
- timeFrame
- until the day 28
Secondary outcomes (5)
- measure
- Number of postoperative infectious episodes per participant, classified by anatomical site, as assessed retrospectively from hospitalization records
- timeFrame
- until the day 28
- description
- Each infectious episode occurring within 28 days after esophagectomy will be retrospectively identified by review of hospitalization records. The anatomical site of infection (e.g., pulmonary, pleural, mediastinal, urinary, abdominal, surgical wound, bloodstream) will be determined based on the description found in medical documentation. The diagnosis of infection will rely on retrospective analysis of recorded clinical signs (e.g., fever), laboratory data (e.g., leukocytosis, elevated CRP), imaging reports (e.g., CT scan, chest X-ray), and physician assessmentsdocumented in the medical file. The unit of measure is : number of infectious episodes per participant. The data will be reported as the total number of episodes and their distribution by anatomical site, summarized per participant and overall using descriptive statistics (median \[IQR\], counts, percentages).
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients over 18 years of age * Underwent esophagectomy for cancer between January 1, 2017, and December 31, 2024 * Scheduled admission to intensive care for postoperative monitoring Exclusion Criteria: * Opposition to the use of data
References
Publications (0)
Data not yet available