FPI-2265 (225Ac-PSMA-I&T) and Olaparib for Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Inclusion Criteria:

1. Adult male participants with mCRPC that is progressing at the time of study entry
2. ECOG performance status 0-1 and life expectancy of at least three months
3. Must have received at least one novel anti-androgen deprivation therapy
4. Participants with known BRCA mutations should have received approved therapies such as PARP inhibitors, per Investigator discretion.
5. All prior treatment-related AEs must have resolved to CTCAE Grade ≤1 (except alopecia).
6. Participants must have had prior orchiectomy and/or ongoing androgen deprivation therapy and a castrate level of serum testosterone (\<50 ng/dL or \<1.7 nmol/L)
7. Positive PSMA PET/CT scans .
8. Participants must have adequate organ and bone marrow function:

   * Hgb \>/= 9g/dL
   * Platelets \>/= 100 x 10\^9/L
   * ANC \</= 1.5 x 10\^9/L
   * CrCL \>/= 50 mL/min

Exclusion Criteria:

1. Previous treatment with any of the following within 6 months of first dose: Samarium-153, Rhenium-186, Rhenium-188, Radium-223, hemi-body irradiation.
2. Participants who received more than two (2) prior lines of cytotoxic chemotherapy for CRPC.
3. Participants with known unresolved urinary tract obstruction.
4. Transfusion- or growth factor-dependent participants.
5. Participants with a history of CNS metastases are excluded, except those who have received therapy (and are neurologically stable, asymptomatic, and not receiving corticosteroids for the purposes of maintaining neurologic integrity.
6. Symptomatic cord compression, or clinical or radiologic findings indicative of impending cord compression.
7. Participants with any liver metastases.
8. Participants with skeletal metastases presenting as a superscan .
9. Previous history of interstitial lung disease or non-infectious pneumonitis.
10. Participants with a history or clinical and/or laboratory features suggestive of MDS/AML.
11. Major surgery ≤28 days prior to the first dose of study treatment.
12. Planning to conceive a pregnancy during the treatment and up to six months after the last treatment.
13. Participants unable to swallow orally administered medications or with malabsorptive gastrointestinal disorders.
14. Concomitant use of known strong or moderate CYP3A inhibitors or inducers