Clinical trial · Interventional
Endoscopic Resection for Small Rectal Neuroendocrine Tumors
Modified Cap-assisted Endoscopic Mucosal Resection and Modified Endoscopic Mucosal Resection with a Ligation Device for Small Rectal Neuroendocrine Tumors Less Than 1 Cm: a Muticenter Randomized Noninferiority Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
According to clinical practice and relevant retrospective research data, both modified cap-assisted endoscopic mucosal resection (mEMR-C) and endoscopic mucosal resection with a ligation device(ESMR-L) were reported to be effective for the treatment of small rectal neuroendocrine tumors (NETs) . However, there is a lack of multicenter prospective studies to evaluate the advantages and disadvantages of mEMR-C and mEMR-L. mEMR-C is the modified ESMR-L without submucosal injection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Neuroendocrine Tumor | Rectal Neuroendocrine Tumor | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| mEMR-C procedure | Procedure | — | UNRESOLVED |
| mEMR-L procedure | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- mEMR-C group
- description
- In mEMR-C group, enrolled patients will receive modified EMR-C without submucosal injection.
- interventionNames
- Procedure: mEMR-C procedure
- type
- ACTIVE_COMPARATOR
- label
- mEMR-L group
- description
- In mEMR-L group, enrolled patients will receive modified ESMR-L without submucosal injection.
- interventionNames
- Procedure: mEMR-L procedure
Primary outcomes (1)
- measure
- histological complete resection
- timeFrame
- within 14 days after procedure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age from 18 to 80 years; 2. With a high suspicion or evidence of rectal NET assessed using EUS or colonoscopy; 3. With tumor size ≤10 mm assessed by colonoscopy; 4. Plan to receive mEMR-C or mEMR-L treatment and provide written informed consent; Exclusion Criteria: 1. Unable to tolerate mEMR-L or mEMR-C as assessed by the research team of each center; 2. Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation; 3. Rectal NET with lymph node metastasis or distant metastasis; 4. Received resection of rectal neuroendocrine tumor by other surgical procedures; 5. Multiple rectal neuroendocrine tumors; 6. Vulnerable groups such as pregnant women or patients with mental disorders; 7. Poor compliance, unable to cooperate with treatment.
References
Publications (0)
Data not yet available