Clinical trial · Observational
TACE Combined Surgery for the Resectable Huge HCC
Transcatheter Arterial Chemoembolization Combined Surgery Versus Surgery for the Resectable Huge Hepatocellular Carcinoma: a Multicenter Propensity Analysis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Huge hepatocellular carcinoma (HCC) is defined as a tumor with a maximum diameter greater than 10 cm. With advancements in surgical techniques, hepatectomy can be performed safely in some patients with huge HCC without vascular invasion or distant metastasis and with preserved liver function. The high risk of recurrence after surgery is another challenge for surgeons. Neoadjuvant TACE has been shown to improve the clinical outcomes of patients with HCC, especially those with a high risk of recurrence, such as those with multinodular tumors, large tumors, and tumor thrombus. The present multicenter study aimed to evaluate the efficacy of neoadjuvant TACE in patients with huge HCC who underwent liver resection.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatic Chemotherapy | — | UNRESOLVED | — |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgery | Procedure | — | UNRESOLVED |
| TACE | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- TACE+surgery
- description
- patients underwent neoadjuvant TACE followed by surgical treatment.
- interventionNames
- Procedure: TACE
- Procedure: Surgery
- label
- Surgery
- description
- patients underwent surgical treatment.
- interventionNames
- Procedure: Surgery
Primary outcomes (1)
- measure
- Recurrence-free survival （RFS）
- timeFrame
- 24 months
- description
- RFS was defined as the time from surgery to tumor progression or the last follow-up
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. clinical or pathological diagnosis of primary HCC; 2. tumor diameter \> 10 cm on images before inclusion; 3. age 18 to 75 years; 4. no macrovascular invasion or extrahepatic metastasis; 5. liver resection with complete removal of the tumor and adequate remnant liver volume; 6. albumin-bilirubin (ALBI) grade I and II; 7. Eastern Cooperative Oncology Group performance status (ECOG) score of 0-1; 8. hemoglobin level ≥ 8.5 g/dL, total bilirubin level ≤ 30 mmol/L, alanine transaminase (ALT) and aspartate aminotransferase (AST) levels ≤ 5 × upper limit of normal, serum creatinine level ≤ 1.5 × upper limit of normal; 9. prothrombin time ≤ 18 s or international normalized ratio \< 1.7. Exclusion Criteria: 1. HCC with macrovascular invasion or extrahepatic metastasis; 2. tumor with a maximum diameter ≤ 10 cm on images before inclusion; 3. recurrent HCC; 4. serious medical comorbidities; 5. portal hypertension, including presence of either esophageal varices or splenomegaly with a platelet count less than 109/L; 6. cardiac ventricular arrhythmias requiring anti-arrhythmic therapy; 7. incomplete data or lost to follow-up within three months.
References
Publications (0)
Data not yet available