Clinical trial · Interventional
Latitude - Lateral Lymph Node Attitude Study
Lateral Lymph Nodes in Rectal Cancer Attitude Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with advanced rectal cancer can sometimes have suspected tumour affected lymph nodes outside the standard operating field. These patients often receive preoperative treatment before surgery. There is a lack of consensus on what to do if there is remaining suspicion of tumour affected lymph nodes after the preoperative treatment. Removal of the lymph nodes using a broader surgical field with dissection of the lateral side-wall is often suggested, but the oncologic outcome is uncertain, and so is the patient reported outcome in terms of side effects. This study aims to study the surgical treatment of tumour affected lateral lymph nodes to understand what lymph nodes require removal, and what effect that will have on oncologic outcome and the patient's function and QoL.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Neoplasm Malignant | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lateral lymph node dissection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Rectal cancer surgery without lateral lymph node dissection
- description
- Rectal cancer surgery without lateral lymph node dissection. Applicable if no lateral lymph nodes on primary MRI or lateral lymph nodes ≤4 mm after neoadjuvant treatment No lateral lymph node dissection
- type
- EXPERIMENTAL
- label
- Rectal cancer surgery with lateral lymph node dissection
- description
- Rectal cancer surgery with lateral lymph node dissection. Applicable if lateral lymph nodes on primary MRI that persist after neoadjuvant treatment (\> 4 mm) . Lateral lymph node dissection
- interventionNames
- Procedure: Lateral lymph node dissection
Primary outcomes (1)
- measure
- Local recurrence
- timeFrame
- Three years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 18 years or older * written informed consent * adenocarcinoma verified tumour below ≤ 8 cm from anal verge measured by rectoscopy and/or MRI * clinical tumor (cT) stage cT3, cT4a or cT4b on MRI or * adenocarcinoma verified tumour at any height ≤ 15 cm from anal verge measured by rectoscopy and/or MRI regardless of T/N stage with visible lateral lymph node (according to definition 2.4.2) on pre-therapeutic MRI or PET-CT Exclusion Criteria: * Not biopsy confirmed rectal cancer (adenocarcinoma) * Recurrent rectal cancer * Age below 18 * Participation in other trials in conflict with the protocol and end-points of the Latitude study * No informed consent
References
Publications (0)
Data not yet available