Clinical trial · Observational
Inside a Neuron - Ex Vivo Evaluation of Cerebral and Cerebellar Neuronal Activity.
Inside a Neuron - Ex Vivo Evaluation of Cerebral and Cerebellar Neuronal Activity Through Electrophysiological and Imaging Techniques on Human Tissue from Surgical Activity.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Understanding the functioning of human neurons has always been a key element, especially with regard to the translation of the inputs they receive into actions that determine human behavior. However, the vast majority of studies have been performed in animal models due to the difficulty in maintaining neuronal functions ex vivo. Recently, techniques have been illustrated that allow us to obtain slices of brain tissue removed during neurosurgical interventions. The patch-clamp and HD-MEA (high density - microelectrodes array) techniques, used until now for animal samples, can allow us to study the functioning of the neural cells that make up these slices. Furthermore, the exploration of the functioning of the aforementioned cells in pathological conditions can open the field for further therapeutic perspectives.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Human Neural Cells Functioning | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Study group
- description
- Patients subdued to neurosurgical intervention for the removal of brain or cerebellum primary or secondary tumor
Primary outcomes (1)
- measure
- Primary endpoint
- timeFrame
- Through study completion, an average of 3 years.
- description
- Intrinsic and extrinsic properties of brain and cerebellum neurons in "health" condition. In particular, following element will be measured: * cell membrane capacity and resistance; * Sodium and Potassium currents; * cell firing frequency.
Secondary outcomes (1)
- measure
- Secondary endpoint
- timeFrame
- Through study completion, an average of 3 years.
- description
- Intrinsic and extrinsic properties of brain and cerebellum neurons in "pathological" condition. In particular, following element will be measured: * cell membrane capacity and resistance; * Sodium and Potassium currents; - cell firing frequency.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients with a brain/cerebellum primary or secondary tumor for whom at least partial resection has been planned. Exclusion Criteria: * patients with a brain/cerebellum primary or secondary tumor for whom a biopsy has been planned
References
Publications (0)
Data not yet available