Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application

Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is overexpressed, individual and combined overexpression of the signature members is able to determine a significant reduction in both migration and invasion. Therefore, ectopic expression of the miRNAs identified by us has a negative impact on cell viability, proliferation and apoptosis, but above all on migration and invasion.

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Inclusion Criteria:

* histological diagnosis of glioma;
* no concomitant primary tumor;
* no metastatic disease;
* availability of surgical material/tissue;
* written informed consent.

Exclusion Criteria:

* histological diagnosis of non-glial tumor;
* patients with concomitant other solid tumors;
* metastatic disease;
* no surgical material/tissue available;
* HIV seropositivity.