MRD-Guided Surveillance in Operable Colon Adenocarcinoma (I-III)(SURVEILLANCE-I)

Inclusion Criteria:

1. Age range: 18-80 years old, male or female not limited;
2. Histologically confirmed colon adenocarcinoma (i.e. adenocarcinoma, including adenocarcinoma, mucinous adenocarcinoma, signet ring cell carcinoma, undifferentiated carcinoma; excluding adenosquamous cell carcinoma);
3. Preoperative staging of stages I-III, without undergoing endoscopic ESD or EMR surgical resection;
4. Not receiving chemotherapy, radiotherapy, targeted therapy, or other anti-tumor treatments;
5. Radical surgery can be performed;
6. ECOG score 0-1 points;
7. The subjects voluntarily joined this study and signed an informed consent form, demonstrating good compliance and actively cooperating to return to the hospital for regular clinical follow-up diagnosis and treatment.

Exclusion Criteria:

1. Previously suffered from other malignant tumors (including non adenocarcinoma colorectal cancer);
2. Pregnant and lactating women;
3. According to the researchers' assessment, the patient also suffers from other diseases that may affect follow-up and short-term survival
4. Subjects have other factors that may lead to the forced termination of this study, such as other serious diseases (including mental illness, infectious diseases, fever ≥ 38 ℃, etc.) requiring combined treatment, serious laboratory examination abnormalities, accompanied by family or social factors, which will affect the safety of subjects, or the collection of data and samples.