Clinical trial · Observational
Role of Elastic Power in Acute Respiratory Distress Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces. VILI results from the interaction between lung structure and mechanical ventilation factors, such as tidal volume, plateau pressure, driving pressure, inspiratory flow, respiratory rate, and PEEP. Intrinsic factors like lung heterogeneity further increase the risk. Elastic power (EP), a key component, is linked to repetitive alveolar stretching and disease progression. Study Objectives: Examine the correlation between elastic power and pulmonary hyperinflation. Compare EP's sensitivity and specificity with other overdistension markers like driving pressure, plateau pressure, upper inflection point, and compliance.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adult Patients | — | UNRESOLVED | — |
| ARDS (Moderate or Severe) | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Comparison between pulmonary hyperinflation and pulmonary elastic power
- timeFrame
- 1 hour
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Adult patients (≥18 years) with moderate-to-severe acute respiratory distress syndrome (ARDS), as defined by the Berlin criteria, were prospectively and consecutively included. \- Exclusion Criteria: Patients were excluded if they met at least one of the following criteria: * History of emphysema, asthma, or pneumothorax. * Severe instability at the time of the study preventing the PEEP titration maneuver, defined by at least one of the following indicators: SaO₂ ≤ 90%, shock requiring \>0.5 γ/kg/min of norepinephrine, complex arrhythmia, myocardial ischemia, or intracranial hypertension refractory to initial treatment. * Patients with do-not-resuscitate orders and pregnant women.
References
Publications (4)
- RESULTXie Y, Shi J, Liu S, Chen X, Wang Y, Li X, Yan Y. Association of elastic power in mechanical ventilation with the severity of acute respiratory distress syndrome: a retrospective study. Eur J Med Res. 2024 Jan 3;29(1):5. doi: 10.1186/s40001-023-01577-7. PMID 38173033
- RESULTModesto I Alapont V, Aguar Carrascosa M, Medina Villanueva A. Stress, strain and mechanical power: Is material science the answer to prevent ventilator induced lung injury? Med Intensiva (Engl Ed). 2019 Apr;43(3):165-175. doi: 10.1016/j.medin.2018.06.008. Epub 2018 Nov 5. No abstract available. English, Spanish. PMID 30409677
- RESULTMarini JJ, Thornton LT, Rocco PRM, Crooke PS. From pressure to tension: a model of damaging inflation stress. Crit Care. 2023 Nov 15;27(1):441. doi: 10.1186/s13054-023-04675-4. PMID 37968744
- RESULTGattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M. The future of mechanical ventilation: lessons from the present and the past. Crit Care. 2017 Jul 12;21(1):183. doi: 10.1186/s13054-017-1750-x. PMID 28701178