Clinical trial · Observational
Pre-malignant States to Hematologic Malignancies in Firefighters
NCT06870760CI-TRIAL-00117732recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Clonal Hematopoiesis of Indeterminate Potential | — | UNRESOLVED | — |
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
| Monoclonal Gammopathy | — | UNRESOLVED | — |
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
| Non Hodgkin Lymphoma | Non-Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Plasma Cell Disorder | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Clonal hematopoiesis (CHIP) | Other | — | UNRESOLVED |
| Complete Blood Count with differential (CBC w/ diff) | Other | — | UNRESOLVED |
| Monoclonal Gammopathy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Firefighter
- description
- Participants employed by the Charlotte Fire Department (CFD) with at least 5 years of on-the-job experience between the ages of 40 and 49
- interventionNames
- Other: Monoclonal Gammopathy
- Other: Complete Blood Count with differential (CBC w/ diff)
- Other: Clonal hematopoiesis (CHIP)
Primary outcomes (1)
- measure
- Clonal Hematopoiesis (CHIP)
- timeFrame
- From enrollment to availability of lab results, approximately 6 months
- description
- The presence of positive somatic mutation will be determined for each enrolled participant as a binary variable indicating if the participant is harboring clonal hematopoiesis.
Secondary outcomes (3)
- measure
- Monoclonal Gammopathy (MGUS)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 49 Years
Show eligibility criteria text
Inclusion Criteria: 1. Written informed consent and HIPAA authorization for release of personal health information. 2. Age ≥ 40-49 years at the time of consent (self-reported) 3. Ability of the participant to understand and comply with study procedures for the entire length of the study 4. Currently employed by Charlotte Fire Department (CFD) with at least 5 years on-the -job experience (self-reported) Exclusion Criteria: Anyone with a current diagnosis of a hematologic malignancy will be excluded.
References
Publications (0)
Data not yet available
No reference posted for this study.