Clinical trial · Observational
Multi-Center Study Protocol: Impact of Sarcopenia in Early-Onset Colorectal Cancer.
Multi-Center Retrospective Study to Evaluate the Impact of Sarcopenia in Patients with Early-Onset Colorectal Cancer: Incidence Risk Factor or Negative Prognosis Predictor?
NCT06868095CI-TRIAL-00087084ISoPECCenrolling by invitationClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Sarcopenia's role in early-onset colorectal cancer (EOCRC), a subtype increasingly diagnosed in individuals under 50 years, has not yet been investigated according to recent literature. Understanding the prevalence and prognostic impact of sarcopenia in EOCRC could inform tailored therapeutic approaches and improve patient outcomes.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Disease-free Survival | — | UNRESOLVED | — |
| Early Onset Colorectal Cancer | — | UNRESOLVED | — |
| Overall Survival | — | UNRESOLVED | — |
| Prognostic Factors | — | UNRESOLVED | — |
| Sarcopenia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgical resection | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Case group
- description
- Patients \< 50 years with diagnosis of colorectal cancer and with diagnosis of sarcopenia and CT-based assessment of skeletal muscle mass
- interventionNames
- Other: Surgical resection
- label
- Control group
- description
- patients \<50 years who had a CT- scan for suspected appendicitis or any other abdominal surgical urgency
Primary outcomes (1)
- measure
- Impact of sarcopenia on the incidence of EOCRC
- timeFrame
- Patients operated from 2000 to 2024 with at least 3 years follow-up
- description
- Evaluation of sarcopenia on the incidence of early-onset colorectal cancer
Secondary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 49 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed EOCRC * Emergency room access for suspected surgical pathology * Age: 18-49 years at diagnosis. * Available baseline CT or MRI scans for sarcopenia assessment Exclusion Criteria: * Presence of comorbidity conditions severely affecting muscle mass unrelated to cancer (e.g., neuromuscular disorders). * Inadequate follow-up data or loss to follow-up * No past oncological history
References
Publications (4)
- BACKGROUNDWeerink LBM, van der Hoorn A, van Leeuwen BL, de Bock GH. Low skeletal muscle mass and postoperative morbidity in surgical oncology: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):636-649. doi: 10.1002/jcsm.12529. Epub 2020 Mar 3. PMID 32125769
- BACKGROUNDPeterson SJ, Mozer M. Differentiating Sarcopenia and Cachexia Among Patients With Cancer. Nutr Clin Pract. 2017 Feb;32(1):30-39. doi: 10.1177/0884533616680354. Epub 2016 Dec 15. PMID 28124947
- BACKGROUNDAro R, Makarainen-Uhlback E, Ammala N, Rautio T, Ohtonen P, Saarnio J, Merilainen S. The impact of sarcopenia and myosteatosis on postoperative outcomes and 5-year survival in curatively operated colorectal cancer patients - A retrospective register study. Eur J Surg Oncol. 2020 Sep;46(9):1656-1662. doi: 10.1016/j.ejso.2020.03.206. Epub 2020 Mar 17. PMID 32224072
- BACKGROUNDRoshandel G, Ghasemi-Kebria F, Malekzadeh R. Colorectal Cancer: Epidemiology, Risk Factors, and Prevention. Cancers (Basel). 2024 Apr 17;16(8):1530. doi: 10.3390/cancers16081530. PMID 38672612