Clinical trial · Interventional
Heterogeneity of Oral Squamous Cell Carcinoma Analysis by Single Cell RNA Sequencing
NCT06861036CI-TRIAL-00086849HOASISnot yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and leucoplasic) counterparts by scRNAseq in OSCC patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Squamous Cell Carcinomas | Oral Cavity Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Biospecimen | Procedure | — | UNRESOLVED |
| Blood sampling | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Clinical-biological cohort
- description
- A clinical-biological cohort of 50 patients with OSCC. Blood sample and biospecimen at the time of a standard surgery.
- interventionNames
- Procedure: Biospecimen
- Procedure: Blood sampling
Primary outcomes (1)
- measure
- Characterization of the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and leucoplasic) counterparts by scRNAseq in OSCC patients.
- timeFrame
- 3 years
- description
- Transcriptomic data from scRNAseq for all cell populations
Secondary outcomes (3)
- measure
- Description of the functional interactions among tumor, stromal, and immune subpopulations identified by scRNAseq
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * I1. Male or female at least 18 years old. * I2. Patient with OSCC and undergoing surgery at the Centre Léon Bérard. * I3. Patient who has agreed to participate in this research and sign consent. * I4. Patient affiliated to a medical insurance. Exclusion Criteria: * NI1. Pregnant or nursing woman. * NI2. Contraindication to general anesthesia. * NI3. Suspicion of rare tumor of particular histology other than squamous cell carcinoma (Sarcoma...). * NI4. Patient under curatorial or guardianship or placed under the protection of justice.
References
Publications (0)
Data not yet available
No reference posted for this study.