Clinical trial · Observational
The Association Between Microplastics and Macrogenomics and Metabolomics in Gastric Cancer
Identification of Paraneoplastic and Intratumor Microplastics in Gastric Cancer and Their Association Analysis With Macrogenomics and Metabolomics
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study was to identify and quantify microplastics in blood, stool, and tumor surgical specimens from gastric cancer patients by analyzing the nature, type, and abundance of microplastics using laser direct infrared (LDIR) spectroscopy, scanning electron microscopy (SEM), and pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS). Meanwhile, combining macro-genomic and metabolomic techniques to explore the association between microplastics and host microbiota and metabolic profiles, and to reveal the potential effects of microplastics on gastric cancer incidence and development will provide new insights into the relationship between microplastic contamination and gastric cancer, as well as an important scientific basis for future public health strategies and cancer prevention and control measures.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancers | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| gastric cancer | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- the gastric cancer group
- description
- patients diagnosed with gastric cancer
- interventionNames
- Diagnostic Test: gastric cancer
Primary outcomes (1)
- measure
- Types of microplastics in gastric cancerous and paracancerous tissues (categorical measure)
- timeFrame
- The date of microplastics testing, assessed up to 1 week after surgery.
- description
- Polymer types of microplastics in gastric tissues Time Frame: Intraoperative sampling Measuring tool: μ-FTIR spectroscopy Unit: Categorical classification (e.g., polyethylene, polypropylene, etc.)
Secondary outcomes (2)
- measure
- Physical-chemical properties of microplastics in gastric cancerous and paracancerous tissues (continuous measure)
- timeFrame
- The date of microplastics testing, assessed up to 1 week after surgery.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age ≥18 years old; * diagnosed with gastric cancer by pathology before surgery and not receiving chemotherapy, radiotherapy or immunotherapy; * no history of other gastrointestinal diseases; * complete clinical data and basic information; * willing to participate in this study and sign an informed consent form. Exclusion Criteria: * Patients receiving neoadjuvant radiotherapy or chemotherapy; * patients with other malignant tumors other than gastric cancer; * patients with incomplete or unclear pathological data; * individuals who are not willing to participate in the study.
References
Publications (0)
Data not yet available