Clinical trial · Interventional
Cardioprotection on Chemotherapy-Induced Cardiotoxicity
The Effect of Cardioprotective Medications on Chemotherapy-Induced Cardiotoxicity in Childhood Acute Leukemia
NCT06853951CI-TRIAL-00086656recruitingPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the present study is to evaluate the protective impact of cardioprotective medications on the chemotherapy- induced cardiotoxicity.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiotoxicity | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ACE Inhibitors | Drug | — | UNRESOLVED |
| β -Blockers | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- ACEIs
- description
- 0.3 mg/kg/dose every 8 hours orally by either a caregiver or caring nurse.
- interventionNames
- Drug: ACE Inhibitors
- type
- ACTIVE_COMPARATOR
- label
- β-blockers
- description
- 0.05 mg/kg/dose every 12 hours orally by either a caregiver or caring nurse
- interventionNames
- Drug: β -Blockers
Primary outcomes (1)
- measure
- Change in Left Ventricular Ejection Fraction (LVEF)
- timeFrame
- LVEF will be measured at Baseline and at the end of Induction Phase (42 Days)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 1 Year
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Willingness of the legal representative of research participant to participate in the study by giving "informed consent." * Ability to take oral medication. * Age 2-18 years at the time of diagnosis. Exclusion Criteria: * Documented allergy to cardioprotective medications
References
Publications (0)
Data not yet available
No reference posted for this study.