Clinical trial · Interventional
Cleaning the Biopsy Needle in TRUS Bx
The Effect of Cleaning the Biopsy Needle With Isopropyl Alcohol, Povidone Iodine and Formalin Before Transrectal Ultrasonography-guided Prostate Biopsy on Procedure-related Infective Complications
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prostate cancer(PCa) is the second most common cancer diagnosed in men. Clinical suspicion of PCa is mentioned in patients with digital rectal examination findings and elevated serum PSA. Despite all the advances in radiological imaging methods, the gold standard method in the diagnosis of the disease is systematic prostate biopsy performed under the guidance of transrectal ultrasonography, which is an invasive procedure. In TRUS-guided transrectal prostate biopsy, bacteriuria may develop as a result of the rectum flora being injected into the urinary system through a biopsy needle. Infective complications may be encountered as a result of this contamination. Infective complications can present with conditions ranging from asymptomatic bacteriuria to sepsis. A study has shown that disinfection of the biopsy needle with isopropyl alcohol reduces sepsis due to prostate biopsy compared to the standard procedure. In another study, disinfection of the biopsy needle tip with formalin was found to be associated with a decrease in infectious complications after transrectal prostate biopsy. In this study, investigators aimed to conduct a prospective study comparing Transrectal Ultrasonography-guided Prostate Biopsy cases, in which the biopsy needle was cleaned with isopropyl alcohol, povidone iodine and formalin, and standard biopsy patients in terms of infectious complications.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostatic Cancer | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| formaldehit | Combination Product | — | UNRESOLVED |
| Isopropyl Alcohol | Drug | — | UNRESOLVED |
| Povidine-iodine | Drug | — | UNRESOLVED |
| Standard BP control | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- biopsy needle with formalin
- interventionNames
- Combination Product: formaldehit
- type
- EXPERIMENTAL
- label
- biopsy needle with povidone iodine
- interventionNames
- Drug: Povidine-iodine
- type
- ACTIVE_COMPARATOR
- label
- Standart biyopsy
- description
- No disinfection method is used in routine use in repetitive procedures when taking a transrectal biopsy.
- interventionNames
- Procedure: Standard BP control
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Oriented-coopere patients * Patients without active urinary tract infection - Patients without active urinary tract infection * Patients without bleeding diathesis * Patients who accept the study Exclusion Criteria: * Patients with active urinary tract infection * Patients with bleeding diathesis * Patients with sonal or cystofix * Patients with a history of previous prostate surgery
References
Publications (1)
- DERIVEDCaglayan MS, Kestel M, Ekici M, Aydin C, Ozturk MI, Tasci A, Baykam MM. Effect of needle disinfection with different antiseptic agents on infectious complications after TRUS-guided prostate biopsy: a prospective randomized study. Ther Adv Urol. 2026 Jun 23;18:17562872261458100. doi: 10.1177/17562872261458100. eCollection 2026 Jan-Dec. PMID 42369177